β-Funaltrexamine hydrochloride
Chemical Name: (E)-4-[[5α,6β)-17-Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-yl]amino]-4-oxo-2-butenoicacid methyl ester hydrochloride
Purity: ≥98%
Biological Activity
β-Funaltrexamine hydrochloride is a selective μ opioid receptor antagonist.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Additional Information
Background References
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Delta opioid receptors: the link between exercise and cardioprotection.
Borges J, Verdoorn K, Daliry A, Powers S, Ortenzi V, Fortunato R, Tibirica E, Lessa M
PLoS ONE, 2014;9(11):e113541. -
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
μ Antagonist and κ agonist properties of β-funaltrexamine (β-FNA) in vivo: long lasting spinal analgesia in mice.
Jiang et al.
J.Pharmacol.Exp.Ther., 1990;252:1006 -
The irreversible narcotic antagonist and reversible agonist properties of the fumarate methyl ester derivative of naltr.
Takemorei et al.
Eur.J.Pharmacol., 1981;70:445
Product Datasheets
Citations for β-Funaltrexamine hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for β-Funaltrexamine hydrochloride include:
7 Citations: Showing 1 - 7
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Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Design, Synthesis, and Evaluation of Analogues with Improved Potency and G-protein Activation Bias at the μ Opioid Receptor.
Authors: Crowley Et al.
ACS Chem Neurosci 2020;11:1781
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Berberine Improves Intestinal Motility and Visceral Pain in the Mouse Models Mimicking Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Symptoms in an Opioid-Receptor Dependent Manner.
Authors: Chen Et al.
Neuropsychopharmacology 2015;10:e0145556
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Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin.
Authors: Romero-Picó Et al.
Circulation 2013;38:1296
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Pain-facilitating medullary neurons contribute to opioid-induced respiratory depression.
Authors: Phillips Et al.
J Neurophysiol 2012;108:2393
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Myricetin Ameliorates Defective Post-Receptor Ins Signaling via β-Endorphin Signaling in the Skeletal Muscles of Fructose-Fed Rats.
Authors: Tzeng Et al.
Evid Based Complement Alternat Med 2011;2011:150752
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Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance.
Authors: Largent-Milnes Et al.
Br J Pharmacol 2010;161:986
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Differential responses to morphine-induced analgesia in the tail-flick test.
Authors: Cecchi Et al.
Behav Brain Res 2008;194:146
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