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BGC 20-1531 hydrochloride

Catalog #: 5327
2 Citations Datasheet / COA / SDS
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5327/10
BGC 20-1531 hydrochloride | CAS No. 1962928-26-2 | Prostanoid Receptor Antagonists
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Description: High affinity and selective EP4 antagonist
Alternative Names: PGN 1531

Chemical Name: 4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity

BGC 20-1531 hydrochloride is a high affinity and selective EP4 antagonist (Ki = 3 nM). Exhibits >2500-fold selectivity for EP4 over EP2 and EP3. Also selective over a range of other prostanoid receptors, ion channels, transporters and enzymes. Inhibits PGE2-induced vasodilation of middle cerebral and meningeal arteries in vitro, and carotid blood flow in vivo. Orally bioavailable.

Technical Data

M.Wt:
529
Formula:
C26H24N2O6S.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1962928-26-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. From virtual to clinical: The discovery of PGN-1531, a novel antagonist of the prostanoid EP4 receptor.
    Sutton et al.
    Bioorg.Med.Chem.Lett., 2014;24:2212

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Citations for BGC 20-1531 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for BGC 20-1531 hydrochloride include:

2 Citations: Showing 1 - 2

  1. Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer.
    Authors: David Et al.
    Cancer Discov  2022;12:1904-1921
  2. Autocrine-paracrine prostaglandin E2 signaling restricts TLR4 internalization and TRIF signaling.
    Authors: Perkins Et al.
    Nat.Immunol.  2018;19:1309

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