BIBO 3304 trifluoroacetate
Chemical Name: N-[(1R)-1-[[[[4-[[(Aminocarbonyl)amino]methyl]phenyl]methyl]amino]carbonyl]-4-[(aminoiminomethyl)amino]butyl]-α-phenyl-benzeneacetamide ditrifluoroacetate
Purity: ≥98%
Biological Activity
BIBO 3304 trifluoroacetate is a high affinity NPY Y1 receptor antagonist (IC50 values are 0.38 and 0.72 nM at human and rat receptors respectively) that displays > 2600-fold selectivity over Y2, Y4 and Y5 receptors. Inhibits NPY- and fasting-induced feeding in vivo following central administration. Also antagonizes anxiolytic-like effects of NPY.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Neuropeptide Y Y1 receptor antagonism increases bone mass in mice.
Bone, 2012;51(1):8-16. -
Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guinea-pig.
Lecklin et al.
Br.J.Pharmacol., 2002;135:2029 -
Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents.
Wieland et al.
Br.J.Pharmacol., 1998;125:549 -
Amygdalar neuropeptide Y Y1 receptors mediate the anxiolytic-like actions of neuropeptide Y in the social interaction test.
Sajdyk et al.
Eur.J.Pharmacol., 1999;368:143
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Citations for BIBO 3304 trifluoroacetate
The citations listed below are publications that use Tocris products. Selected citations for BIBO 3304 trifluoroacetate include:
11 Citations: Showing 1 - 10
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Photo-induced receptor confinement drives ligand-independent GPCR signaling.
Authors: Sanchez Et al.
Science 2021;371
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Neuropeptide Y and cannabinoids interaction in the amygdala after exposure to shock and reminders model of PTSD
Authors: Maymon Et al.
Neuropharmacology 2019;162
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Elevated Neuropeptide Y in Endothelial Dysfunction Promotes Macrophage Infiltration and Smooth Muscle Foam Cell Formation.
Authors: Choi Et al.
Front Immunol 2019;10:1701
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A Neural Circuit for the Suppression of Pain by a Competing Need State.
Authors: Alhadeff Et al.
Cell 2018;173:140
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Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions In Vitro.
Authors: Martins Et al.
ASN Neuro 2015;7
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Diurnal fluctuations in HPA and neuropeptide Y-ergic systems underlie differences in vulnerability to traumatic stress responses at different zeitgeber times.
Authors: Cohen Et al.
J Neurosci 2015;40:774
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The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo.
Authors: Panaro Et al.
Neuropsychopharmacology 2014;20:1018
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Deconstruction of a neural circuit for hunger.
Authors: Atasoy Et al.
Cell Metab 2012;488:172
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Activation of NPY receptors suppresses excitatory synaptic transmission in a taste-feeding network in the lower brain stem.
Authors: Chen Et al.
Am J Physiol Regul Integr Comp Physiol 2012;302:R1401
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A role for endogenous peptide YY in tachykinin NK(2) receptor-triggered 5-HT release from guinea pig isolated colonic mucosa.
Authors: Kojima Et al.
Br J Pharmacol 2012;167:1362
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Effect of pharmacological manipulations of neuropeptide Y and corticotropin-releasing factor neurotransmission on incubation of conditioned fear.
Authors: Pickens Et al.
Neuroscience 2009;164:1398
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