Biotinyl Tyramide
Chemical Name: (3aS,4S,6aR)-Hexahydro-N-[2-(4-hydroxyphenyl)ethyl]-2-oxo-1H-thieno[3,4-d]imidazole-4-pentanamide
Purity: ≥98%
Biological Activity
Biotinyl Tyramide is a reagent widely used for signal amplification in IHC and fluorescent in situ hybridization (ISH) and APEX proximity labeling. HRP catalyzes localized deposition of multiple biotinyl tyramide molecules (catalyzed reporter deposition, CARD), which can be detected using a labeled streptavidin conjugate. The localization of deposition around HRP leads to good resolution. Suitable for either fluorescence or chromogenic detection. Biotinyl Tyramide is used as a substrate for APEX proximity labeling.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Catalyzed reporter deposition, a novel method of signal amplification. Application to immunoassays.
Bobrow et al.
J.Immunol.Methods, 1989;125:279 -
Amplification of fluorescent in situ hybridisation signals in formalin fixed paraffin wax embedded sections of colon tumour using biotinylated tyramide.
McKay et al.
Mol.Pathol., 1997;50:322
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Citations for Biotinyl Tyramide
The citations listed below are publications that use Tocris products. Selected citations for Biotinyl Tyramide include:
2 Citations: Showing 1 - 2
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Proximity-based labeling reveals DNA damage-induced phosphorylation of fused in sarcoma (FUS) causes distinct changes in the FUS protein interactome.
Authors: Nicholas T Et al.
J Biol Chem 2022;298:102135
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The Development of Hindlimb Postural Asymmetry Induced by Focal Traumatic Brain Injury Is Not Related to Serotonin 2A/C Receptor Expression in the Spinal Cord.
Authors: Jonas Et al.
Int J Mol Sci 2022;23
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