BIRB 796
Chemical Name: N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea
Purity: ≥98%
Biological Activity
BIRB 796 is a high affinity and selective p38 kinase inhibitor (Kd = 50-100 pM). Exhibits no significant inhibition on a panel of related kinases. Inhibits LPS-induced TNFα production in human PBMCs and whole blood (IC50 values are 21 and 960 nM, respectively). Also inhibits JNK2α2 and c-Raf-1 (IC50 values are 98 nM and 1.4 μM, respectively). BIRB 796 can be used in protocols for the chemical reprogramming of somatic cells to iPSCs. Cell permeable.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region.
Laufer et al.
J.Med.Chem., 2008;51:4122 -
Structure-activity relationships of the p38alpha MAP kinase inhibitor 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796).
Regan et al.
J.Med.Chem., 2003;46:4676 -
Selective p38α inhibitors clinically evaluated for the treatment of chronic inflammatory disorders.
Goldstein et al.
J.Med.Chem., 2010;53:2345
Product Datasheets
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Citations for BIRB 796
The citations listed below are publications that use Tocris products. Selected citations for BIRB 796 include:
12 Citations: Showing 1 - 10
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CDK4/6 inhibitor-mediated cell overgrowth triggers osmotic and replication stress to promote senescence.
Authors: Crozier Et al.
Mol.Cell 2023;83:4062
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Human distal lung maps and lineage hierarchies reveal a bipotent progenitor.
Authors: Richard C Et al.
Nature 2022;604:111-119
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Defined conditions for long-term expansion of murine and human alveolar epithelial stem cells in three-dimensional cultures.
Authors: Aleksandra Et al.
STAR Protoc 2022;3:101447
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Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response.
Authors: Simon Et al.
Cell Metab 2022;34:2036-2046.e8
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Regulation of Stress-Activated Kinases in Response to Tacaribe Virus Infection and Its Implications for Viral Replication.
Authors: Lucie Et al.
Viruses 2022;14
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An In Vitro Microfluidic Alveolus Model to Study Lung Biomechanics.
Authors: Shyni Et al.
Front Bioeng Biotechnol 2022;10:848699
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p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway.
Authors: Markus Et al.
Cell Stress 2021;5:176-182
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Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction.
Authors: Richard C Et al.
Cell Stem Cell 2020;27:890-904.e8
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Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration.
Authors: Harold A Et al.
Cell Stem Cell 2020;26:346-358.e4
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Clinically Advanced p38 Inhibitors Suppress DUX4 Expression in Cellular and Animal Models of Facioscapulohumeral Muscular Dystrophy.
Authors: Stephen J Et al.
J Pharmacol Exp Ther 2019;370:219-230
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Acute inflammation down-regulates alpha-synuclein expression in enteric neurons.
Authors: Michel Et al.
J Neurochem 2019;148:746-760
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Differential effect of p38 and MK2 kinase inhibitors on the inflammatory and toxicity biomarkers in vitro.
Authors: Singh Et al.
Hum Exp Toxicol 2018;37:521
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