BIX NHE1 inhibitor

Catalog #: 5512
1 Citation Datasheet / COA / SDS

Catalog #	Availability	Size / Price
5512/10	Contact your distributor for availability.	10 mg / Please Inquire
5512/50	Contact your distributor for availability.	50 mg / Please Inquire

BIX NHE1 inhibitor | CAS No. 1422252-46-7 | Na+/Ca2+ Exchanger Inhibitors

1 Image

Description: Potent and selective NHE1 inhibitor

Chemical Name: 4-(1-Acetyl-4-piperidinyl)-N-(aminoiminomethyl)-3-(trifluoromethyl)benzamide hydrochloride

Purity: ≥98%

View All Products for Na+/Ca2+ Exchanger Inhibitors

Product Details

Citations (1)

Supplemental Products

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

BIX NHE1 inhibitor is a potent and selective NHE1 inhibitor (IC₅₀ = 31 nM). Selective for NHE1 over NHE2 and NHE3. Prevents ischemic damage in an ischemia reperfusion injury isolated rat heart model ex vivo. Prevents phenylephrine-induced cardiomyocyte hypertrophy in vitro, and attenuates cardiac hypertrophy and left ventricular dysfunction postinfarction in rats. Orally bioavailable.

Technical Data

M.Wt:

392.8

Formula:

C₁₆H₁₉F₃N₄O₂.HCl

Solubility:

Soluble to 50 mM in DMSO

Purity:

≥98%

Storage:

Desiccate at RT

CAS No:

1422252-46-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Customers also Viewed

Human VISTA/B7-H5/PD-1H Alexa Fluor® 350-conjugated Antibody

Cat # FAB71261U

Background References

Identification of a potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor with a suitable profile for chronic dosing and demonstrated cardioprotective effects in a preclinical model of myocardial infarction in the rat.
Huber et al.
J.Med.Chem., 2012;55:7114
Early and transient sodium-hydrogen exchanger isoform 1 inhibition attenuates subsequent cardiac hypertrophy and heart failure following coronary artery ligation.
Kilić et al.
J.Pharmacol.Exp.Ther., 2014;351:492

Product Datasheets

COA view current batch

SDS

Reconstitution Calculator

Molarity Calculator

Citation for BIX NHE1 inhibitor

The citations listed below are publications that use Tocris products. Selected citations for BIX NHE1 inhibitor include:

1 Citation: Showing 1 - 1

Adhesion-mediated mechanosignaling forces mitohormesis.
Authors: Valerie M Et al.
Cell Metab 2021;33:1322-1341.e13

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for BIX NHE1 inhibitor

There are currently no reviews for this product. Be the first to review BIX NHE1 inhibitor and earn rewards!

Have you used BIX NHE1 inhibitor?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.