Home / Adrenergic alpha-1 Receptor Agonists / (R)-(-)-Phenylephrine hydrochloride

(R)-(-)-Phenylephrine hydrochloride

Catalog #: 2838
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2838/100
(R)-(-)-Phenylephrine hydrochloride | CAS No. 61-76-7 | Adrenergic alpha-1 Receptor Agonists
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Description: α1 agonist

Chemical Name: (R)-(-)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride

Purity: ≥99%

Product Details
Citations (4)
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Biological Activity

(R)-(-)-Phenylephrine hydrochloride is a α1-adrenoceptor agonist; pKi values are 5.86, 4.87 and 4.70 for α1D, α1B and α1A receptors respectively.

Scientific Data

Binding Activity phenylephrine affects cardiomyocyte contraction rates View Larger

Small molecules affect cardiomyocyte contraction rates. The effect of small molecules on cardiomyocyte contraction rate was assessed by monitoring intracellular calcium fluctuations, where an increase in calcium coincides with cardiomyocyte contraction. Cardiomyocytes were loaded with the fluorescent calcium indicator, Fluo-4, prior to small molecule treatment. Individual wells were first monitored for baseline rates of calcium fluctuation represented as beats per minute (bpm). Phenylephrine (3μM, Catalog # 2838), an alpha 1-adrenoceptor agonist, increased the calcium fluctuation rate of cardiomyocytes compared to untreated cells

Technical Data

M.Wt:
203.67
Formula:
C9H13NO2.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
61-76-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for (R)-(-)-Phenylephrine hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for (R)-(-)-Phenylephrine hydrochloride include:

4 Citations: Showing 1 - 4

  1. Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence.
    Authors: Chai Et al.
    Neuron  2017;95:531
  2. Selumetinib, an Oral Anti-Neoplastic Drug, May Attenuate Cardiac Hypertrophy via Targeting the ERK Pathway.
    Authors: Li Et al.
    PLoS One  2016;11:e0159079
  3. Sodium salicylate suppresses GABAergic inhibitory activity in neurons of rodent dorsal raphe nucleus.
    Authors: Jin Et al.
    J Neurosci  2015;10:e0126956
  4. Leptin does not directly affect CNS serotonin neurons to influence appetite.
    Authors: Lam Et al.
    PLoS One  2011;13:584

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