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BMS 191011

Catalog #: 2665
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2665/10
2665/50
BMS 191011 | CAS No. 202821-81-6 | Ca2+-Activated Potassium Channel Activators
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Description: Potent KCa1.1 (BK) channel opener

Chemical Name: 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

BMS 191011 is a potent BKCa channel opener (large-conductance Ca2+-activated potassium channel, KCa1.1). Neuroprotectant in two distinct animal models of stroke (MCAO in the SHR rat and a normotensive model of focal stroke).

Technical Data

M.Wt:
370.71
Formula:
C16H10ClF3N2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
202821-81-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. 3-[(5-chloro-2-hydroxyphenyl)methyl]-5-[4-trifluoromethyl)phenyl]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca2+-activated potassium (Maki-K) channels, identification, solubility, and SAR.
    Romine et al.
    J.Med.Chem., 2007;50:528
  2. Synthesis of water-soluble prodrugs of BMS-191011: a Maxi-K channel opener targeted for post-stroke neuroprotection.
    Hewawasam et al.
    Bioorg.Med.Chem.Letts., 2003;13:1695

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Citations for BMS 191011

The citations listed below are publications that use Tocris products. Selected citations for BMS 191011 include:

3 Citations: Showing 1 - 3

  1. Interleukin-22 binding protein (IL-22BP) is constitutively expressed by a subset of conventional dendritic cells and is strongly induced by retinoic acid.
    Authors: Martin Et al.
    Mucosal Immunol  2014;7:101
  2. Maternal nutrient restriction during pregnancy impairs an endothelium-derived hyperpolarizing factor-like pathway in sheep fetal coronary arteries.
    Authors: Shukla Et al.
    Am J Physiol Heart Circ Physiol  2014;307:H134
  3. Naturally occurring eccentric cleavage products of provitamin A β-carotene function as antagonists of retinoic acid receptors.
    Authors: Eroglu Et al.
    Int J Neuropsychopharmacol  2012;287:15886

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