BMS 453
Discontinued Product
Chemical Name: 4-[(1E)-2-(5,6-Dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethenyl]-benzoic acid
Purity: ≥98%
Biological Activity
BMS 453 is a synthetic retinoid. Retinoic acid receptor β (RARβ) agonist in vivo; RARα and RARγ antagonist in vitro. Inhibits breast cell proliferation by inducing active transforming growth factor β (TGFβ) and causes G1 arrest.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Commitment of mouse embryonic stem cells to the adipocyte lineage requires retinoic acid receptor beta and active GSK3.
Monteiro et al.
Stem Cells Dev., 2009;18:457 -
RAR-specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation.
Chen et al.
EMBO J., 1995;14:1187 -
The retinoic acid receptor antagonist, BMS543, inhibits normal breast cell growth by inducing active TGFB and causing cell cycle arrest.
Yang et al.
Oncogene, 2001;20:8025
Product Datasheets
Citations for BMS 453
The citations listed below are publications that use Tocris products. Selected citations for BMS 453 include:
3 Citations: Showing 1 - 3
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Transcriptome analysis of Xenopus orofacial tissues deficient in retinoic acid receptor function.
Authors: Wahl Et al.
BMC Genomics 2018;19:795
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BMP and retinoic acid regulate anterior-posterior patterning of the non-axial mesoderm across the dorsal-ventral axis.
Authors: Naylor Et al.
Nat Commun 2016;7:12197
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Retinoic acid induces blood-brain barrier development.
Authors: Mizee Et al.
J Neurosci 2013;33:1660
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