BMS 470539 dihydrochloride
Chemical Name: 1-[1-(3-Methyl-L-histidyl-O-methyl-D-tyrosyl)-4-phenyl-4-piperidinyl]-1-butanone dihydrochloride
Purity: ≥98%
Biological Activity
BMS 470539 dihydrochloride is a potent, selective melanocortin MC1 receptor agonist (IC50 = 120 nM). Exhibits anti-inflammatory properties following ischemia-reperfusion in the vasculature. Inhibits leukocyte trafficking.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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A selective small molecule agonist of the melanocortin-1 receptor inhibits lipopolysaccharide-induced cytokine accumulation and leukocyte infiltration in mice.
Kang
J.Leukoc.Biol., 2006;80:897 -
Discovery of tyrosine-based potent and selective melanocortin-1 receptor small-molecule agonists with anti-inflammatory properties.
Herpin et al.
J.Med.Chem., 2003;46:1123 -
The melanocortin MC1 receptor agonist BMS-470539 inhibits leukocyte trafficking in the inflamed vasculature.
Leoni et al.
Br.J.Pharmacol., 2010;160:171
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Citation for BMS 470539 dihydrochloride
The citations listed below are publications that use Tocris products. Selected citations for BMS 470539 dihydrochloride include:
1 Citation: Showing 1 - 1
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Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors.
Authors: Jain Et al.
Am J Physiol Endocrinol Metab 2018;315:E357
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