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BMS 961

Catalog #: 3410
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3410/10
3410/50
BMS 961 | CAS No. 185629-22-5 | Retinoic Acid Receptor Agonists
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Description: Selective RARγ agonist

Chemical Name: 3-Fluoro-4-[[2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8,-tetrahydro-2-naphthalenyl)acetyl]amino]-benzoic acid

Purity: ≥97%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

BMS 961 is a selective RARγ agonist (EC50 values are 30 and 1000 nM at RARγ and RARβ respectively). Displays no activity at RARα receptors.

Technical Data

M.Wt:
399.46
Formula:
C23H26FNO4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at +4°C
CAS No:
185629-22-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Retinoids induce integrin-independent lymphocyte adhesion through RAR-alpha nuclear receptor activity.
    Whelan J, Wang L, Chen J, Metts M, Nasser T, McGoldrick L, Bridges L
    Biochem Biophys Res Commun, 2014;454(4):537-542.
  2. Cell-type and promoter-context dependent retinoic acid receptor (RAR) redundancies for RARβ2 and Hoxa-1 activation in F9 and P19 cells can be artefactually generated by gene knockouts.
    Taneja et al.
    Proc.Natl.Acad.Sci.USA, 1996;93:6197
  3. Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor γ and retinoid X receptor α.
    Abu-Abed et al.
    J.Biol.Chem., 1998;273:2409
  4. Enantiomer discrimination illustrated by high-resolution crystal structures of the human nuclear receptor hRARγ.
    Klaholz et al.
    Proc.Natl.Acad.Sci., 2000;97:6322

Product Datasheets

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Reconstitution Calculator

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Citations for BMS 961

The citations listed below are publications that use Tocris products. Selected citations for BMS 961 include:

3 Citations: Showing 1 - 3

  1. Effects of retinoic acid receptor-γ on the Aspergillus fumigatus induced innate immunity response in human corneal epithelial cells.
    Authors: Wang Et al.
    Int J Ophthalmol  2016;9:1713
  2. ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
    Authors: Chronopoulos Et al.
    Nature Communications  2016;7:12630
  3. Cellular and molecular determinants of all-trans retinoic acid sensitivity in breast cancer: Luminal phenotype and RARα expression.
    Authors: Centritto Et al.
    PLoS Pathog  2015;7:950

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