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Bobcat339

Catalog #: 6977 Datasheet / COA / SDS
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6977/50
6977/10

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Bobcat339 | CAS No. 2280037-51-4 | Other Oxidase/Oxygenase Compounds
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Description: Ten-eleven translocation methylcytosine dioxygenase (TET) inhibitor

Chemical Name: 4-Amino-1-[1,1'-biphenyl]-3-yl-5-chloro-2(1H)-pyrimidinone

Purity: ≥98%

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Biological Activity

Bobcat339 is a selective cytosine-based inhibitor of ten-eleven translocation methylcytosine dioxygenase (TET) (IC50 values are 33 and 73 μM for TET1 and TET2, respectively). Bobcat339 reduces DNA 5-hydroxymethylcytosine (5hmC) levels in cells without inhibiting the DNA methyltransferase DNMT3a.

Technical Data

M.Wt:
297.74
Formula:
C16H12ClN3O
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2280037-51-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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