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Boc-MLF

Catalog #: 3730
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3730/1
Boc-MLF
1 Image
Description: FPR1 antagonist

Purity: ≥95%

Product Details
Citations (2)
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Biological Activity

Boc-MLF is an antagonist of formyl peptide receptor 1 (FPR1). Reduces superoxide production induced by fMLF with an EC50 of 0.63 μM. Almost completely blocks fMLF-stimulated primary granule exocytosis.

Technical Data

M.Wt:
509.66
Formula:
C25H39N3O6S
Sequence:
Boc-MLF
Solubility:
Soluble to 2 mg/ml in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
67247-12-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The immunostimulatory peptide WKYMVm-NH2 activates bone marrow mouse neutrophils via multiple signal transduction pathways.
    Boxio et al.
    Scand.J.Immunol., 2005;62:140
  2. Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors.
    Karlsson et al.
    J.Leuko.Biol., 2005;78:762
  3. Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor.
    Stenfeldt et al.
    Inflammation, 2007;30:224
  4. The Antimicrobial Peptide Cathelicidin Exerts Immunomodulatory Effects via Scavenger Receptors
    R Amagai, T Takahashi, H Terui, T Fujimura, K Yamasaki, S Aiba, Y Asano
    International Journal of Molecular Sciences, 2023;24(1):.

Product Datasheets

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Citations for Boc-MLF

The citations listed below are publications that use Tocris products. Selected citations for Boc-MLF include:

2 Citations: Showing 1 - 2

  1. The formyl peptide receptor agonist FPRa14 induces differentiation of Neuro2a mouse neuroblastoma cells into multiple distinct morphologies which can be specifically inhibited with FPR antagonists and FPR knockdown using siRNA.
    Authors: Cussell Et al.
    PLoS One  2019;14:e0217815
  2. Designer cells programming quorum-sensing interference with microbes.
    Authors: Sedlmayer Et al.
    Nat Commun  2018;9:1822

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