Brain natriuretic peptide (1-32) (human)
Purity: ≥95%
Biological Activity
Brain natriuretic peptide (1-32) (human) is an endogenous peptide secreted from cardiac ventricles in response to volume increase and pressure overload that acts as an agonist at atrial natriuretic peptide (ANP) receptor A (NRP1). Decreases de novo collagen synthesis and increases MMP gene expression in vitro. Exhibits natriuretic, vasodilatory and lusitropic activity and inhibits the sympathetic and renin-angiotensin-aldosterone systems in vivo.Technical Data
(Modification: Disulfide bridge: 10-26)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Brain natriuretic peptide is produced in cardiac fibroblasts and induces matrix metalloproteinases.
Tsuruda et al.
Circ.Res., 2002;91:1127 -
Natriuretic peptides, but not nitric oxide donors, elevate levels of cytosolic guanosine 3',5'-cyclic monophosphate in ependymal cells ex vivo.
Wellard et al.
Neurosci.Lett., 2006;392:187 -
Immunoreactivity and guanosine 3',5'-cyclic monophosphate activating actions of various forms of human B-type natriuretic peptide.
Heublein et al.
Hypertension, 2007;49:1114
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Citation for Brain natriuretic peptide (1-32) (human)
The citations listed below are publications that use Tocris products. Selected citations for Brain natriuretic peptide (1-32) (human) include:
1 Citation: Showing 1 - 1
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GDF15 is a heart-derived hormone that regulates body growth.
Authors: Wang Et al.
EMBO Mol Med 2017;9:1150
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