Bretazenil
Chemical Name: (13aS)-8-Bromo-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylic acid 1,1-dimethylethyl ester
Purity: ≥98%
Biological Activity
Bretazenil is a partial agonist at the GABAA benzodiazepine site (EC50 = 10 nM at α1β1γ2 receptors). Displays anticonvulsive activity in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Anticonvulsant tolerance and withdrawal characteristics of benzodiazepine receptor ligands in different seizure models in mice. Comparison of D.pam, bretazenil and abecarnil.
Rundfeldt et al.
J.Pharmacol.Exp.Ther., 1995;275:693 -
Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at γ-aminobutyric acid type A receptor.
Puia et al.
Proc.Natl.Acad.Sci. USA Neurobiology, 1992;89:3620 -
Comparison of the novel subtype-selective GABAA receptor-positive allosteric modulator NS11394 [3'-[5-(1-hydroxy-1-methyl-ethyl)-benzoimidazol-1-yl]-biphenyl-2-carbonitrile] with D.pam, zolpidem, bretazenil, and gaboxadol in rat models of i
Munro et al.
J.Pharmacol.Exp.Ther., 2008;327:969
Product Datasheets
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