BRL 37344, sodium salt
Chemical Name: (R*,R*)-(±)-4-[2-[(2-(3-Chlorophenyl)-2-hydroxyethyl)amino]propyl]phenoxyacetic acid, sodium salt
Purity: ≥98%
Biological Activity
BRL 37344, sodium salt is a potent and selective β3 adrenoceptor agonist (Ki values are 287, 1750 and 1120 nM for β3, β1 and β2 receptors respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
The essential role for aromatic cluster in the beta3 adrenergic receptor.
Acta Pharmacol. Sin., 2012;33(8):1062-8. -
BRL37344, but not CGP12177, stimulates fuel oxidation by soleus muscle in vitro.
Board et al.
Eur.J.Pharmacol., 2000;406:33 -
Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs.
Arch et al.
Nature, 1984;309:163 -
The selectivity in vitro of the sterioisomers of the beta-3 adrenoreceptor agonist BRL 37344.
Ayo Oriowo et al.
J.Pharmacol.Exp.Ther., 1996;277:22 -
Function and regulation of the β3-adrenoceptor.
Strosberg and Pietri-Rouxel
TiPS, 1996;17:373
Product Datasheets
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Citations for BRL 37344, sodium salt
The citations listed below are publications that use Tocris products. Selected citations for BRL 37344, sodium salt include:
10 Citations: Showing 1 - 10
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β2-Adrenergic Receptor Antagonism Attenuates CNV Through Inhibition of VEGF and IL-6 Expression.
Authors: Lavine
Invest Ophthalmol Vis Sci 2017;58(1):299
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Recruitment of β-arrestin 1 and 2 to the β2-adrenoceptor: analysis of 65 ligands.
Authors: Littmann Et al.
Dev Neurosci 2015;355:183
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Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat.
Authors: Suárez Et al.
Dis Model Mech 2014;7:129
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Attenuation of choroidal neovascularization by β(2)-adrenoreceptor antagonism.
Authors: Lavine Et al.
JAMA Ophthalmol 2013;131:376
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Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons.
Authors: Rankovic Et al.
PLoS One 2011;6:e27474
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Ectopic activity in the rat pulmonary vein can arise from simultaneous activation of alpha1- and beta1-adrenoceptors.
Authors: Maupoil Et al.
Br J Pharmacol 2007;150:899
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Direct demonstration of beta1- and evidence against beta2- and beta3-adrenoceptors, in smooth muscle cells of rat small mesenteric arteries.
Authors: Briones Et al.
Br J Pharmacol 2005;146:679
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ALpha1-adrenoceptor antagonist properties of CGP 12177A and other beta-adrenoceptor ligands: evidence against beta(3)- or atypical beta-adrenoceptors in rat aorta.
Authors: Brahmadevara Et al.
Br J Pharmacol 2004;142:781
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β 3-adrenergic receptors regulate retinal endothelial cell migration and proliferation.
Authors: Steinle Et al.
J Pharmacol Exp Ther 2003;278:20681
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Involvement of β 3-adrenergic receptor activation via cyclic GMP- but not NO-dependent mechanisms in human corpus cavernosum function.
Authors: Cirino Et al.
J Biol Chem 2003;100:5531
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