BU 224 hydrochloride

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
   Fox JT, Sakamuru S, Huang R
   Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
2. Locomotor effects of imidazoline I₂-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxyDA lesion of the nigrostriatal pathway.
   MacInnes and Dut
   Br.J.Pharmacol., 2004;143:952
3. Novel selective compounds for the investigation of imidazoline receptors.
   Hudson et al.
   Ann.N.Y.Acad.Sci., 1999;881:81
4. Affinity and selectivity of BU224 and BU239 for rabbit brain non-adrenoceptor idazoxan binding sites (I₂) sites).
   Hudson et al.
   Br.J.Pharmacol., 1994;112:320P
5. Activation of I₂-imidazoline receptors enhances supraspinal mor. analgesia in mice: a model to detect agonist and antagonist activities at these receptors.
   Sanchez-Blasquez et al.
   Br.J.Pharmacol., 2000;130:146

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