Buspirone hydrochloride
Chemical Name: 8-[4-[4-(2-Pyrimidinyl)-1-pipirazinyl]butyl]-8-azaspiro[4,5]decane-7,9-dione hydrochloride
Purity: ≥99%
Biological Activity
Buspirone hydrochloride is a classic 5-HT1A partial agonist with relatively high affinity (Ki = 9.3 - 29.5 nM). A clinically effective anxiolytic.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Buspirone - a preliminary review on its pharmacological properties and therapeutic efficacy as an anxiolytic.
Goa and Ward
Drugs, 1986;32:114 -
Comparative behavioural profiles of busp. and its metabolite 1-(2-pyrimidinyl)-piperazine (1-PP) in the murine elevated plus-maze.
Cao and Rodgers
Neuropharmacology, 1997;36:1089 -
Buspirone modulates basal and fluoxetine-stimulated dialysate levels of DA, noradrenaline and serotonin in the frontal cortex of freely moving rats: activation of serotonin1A receptors and blockade of α2-adrenoceptors underlie i
Gobert et al.
Neuroscience, 1999;93:1251
Product Datasheets
Citations for Buspirone hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Buspirone hydrochloride include:
4 Citations: Showing 1 - 4
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Functional characterization of 5-HT1A and 5-HT1B serotonin receptor signaling through G-protein-activated inwardly rectifying K+ channels in a fluorescence-based membrane potential assay.
Authors: Gadgaard & Jensen
Biochem Pharmacol 2020;175
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Endothelin neurotransmitter signalling controls zebrafish social behaviour.
Authors: Gutierrez Et al.
Sci Rep 2019;9:3040
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The three-spined stickleback as a model for behavioural neuroscience.
Authors: Norton and Gutiérrez
PLoS One 2019;14:e0213320
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Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
Authors: Garavaglia Et al.
BMC Neurosci 2010;11:7
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