Butabindide oxalate
Discontinued Product
Chemical Name: (2S)-[1-[(2S)-2-amino-1-oxobutyl]-N-butyl]-2,3-dihydro-1H-indole-2-carboxamide oxalate
Purity: ≥99%
Biological Activity
Butabindide oxalate is a high affinity, reversible, selective and competitive inhibitor of a CCK-inactivating serine protease (tripeptidyl peptidase II) (Ki = 7 nM). Active in vivo (ID50 = 1.1 and 6.8 mg/kg i.v. for inhibition of liver and brain enzyme respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells.
Dasgupta S, Castro L, Dulman R, Yang C, Schmidt M, Ferro E, Fricker L
PLoS ONE, 2014;9(7):e103604. -
Inhibitors of tripeptidyl peptidase II. 2. Generation of the first novel lead inhibitor of cholecystokinin-8-inactivating peptidase: a strategy for the design of peptidase inhibitors.
Ganellin et al.
J.Med.Chem., 2000;43:664 -
Characterization and inhibition of a cholecystokinin-inactivating serine peptidase.
Rose et al.
Nature, 1996;380:403 -
Characterization and cloning of tripeptidyl peptidase II from the fruit fly, Drosophila melanogaster.
Renn et al.
J.Biol.Chem., 1998;273:19173
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Citations for Butabindide oxalate
The citations listed below are publications that use Tocris products. Selected citations for Butabindide oxalate include:
3 Citations: Showing 1 - 3
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Proteasome inhibitors alter levels of intracellular peptides in HEK293T and SH-SY5Y cells.
Authors: Dasgupta Et al.
PLoS One 2014;9:e103604
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Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells.
Authors: Lorente Et al.
J Biol Chem 2011;286:38054
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Tripeptidyl Peptidase II Is Required for c-MYC-Induced Centriole Overduplication and a Novel Therapeutic Target in c-MYC-Associated Neoplasms.
Authors: Duensing Et al.
Genes Cancer 2010;1:883
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