C 21
Discontinued Product
5128 has been discontinued.
View all Protein Arginine Methyltransferase Inhibitors products.
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Description: Selective PRMT1 inhibitor
Biological Activity
C 21 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.8 μM). Exhibits five-fold selectivity for PRMT1 over PRMT6 and >250-fold selectivity over PRMT3 and CARM1.Technical Data
M.Wt:
2166.94
Formula:
C90H161ClN36O24
Sequence:
SGXGKGGKGLGKGGAKRHRKV
(Modifications: Ser-1 = N-terminal Ac, X = N5-(2-Chloro-1-iminoethyl)]-Orn)
Solubility:
Soluble to 2 mg/ml in water
Storage:
Store at -20°C
CAS No:
1229236-78-5
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation.
Obianyo et al.
Chembiochem, 2010;11:1219 -
Kinetic mechanism of protein arginine methyltransferase 6 (PRMT6).
Obianyo and Thompson
J.Biol.Chem., 2012;287:6062
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