C. botulinum BoNT-C1 Heavy Chain Receptor Binding Domain Antibody
C. botulinum BoNT-C1 Heavy Chain Receptor Binding Domain Antibody Summary
Asn866-Glu1291
Accession # P18640
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Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: BoNT-C1 Heavy Chain
BoNT-C1 (Botulinum neurotoxin C1 [heavy chain]) is a 100 kDa C-terminal fragment of the C1 Clostridum botulinum neurotoxin (holo)precursor. It constitutes a nonenzymatic part of a Zn2+-dependent M27 family endoprotease that potently blocks neurosecretion. The inactive 1291 amino acid (aa), 150 kDa C1 precursor is cleaved between Lys449Thr450 to generate a heterodimeric toxin held together by a preexisting interchain disulfide bond between Cys437 and Cys453. The 100 kDa C-terminus (heavy chain) acts as a ligand for neuronal membrane ecto-acceptors, inducing its translocation and internalization. The 50 kDa N-terminal light chain acts as an intracellular peptidase that cleaves SNAP-25 and syntaxin. This is suggested to block noradrenalin release from a readily releasable pool of vesicles. Over aa 866-1291, the C1 heavy chain shares less than 40% aa identity with the D-type neurotoxin heavy chain.
Product Datasheets
Citation for C. botulinum BoNT-C1 Heavy Chain Receptor Binding Domain Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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Neuronal delivery of antibodies has therapeutic effects in animal models of botulism
Authors: Patrick M. McNutt, Edwin J. Vazquez-Cintron, Luis Tenezaca, Celinia A. Ondeck, Kyle E. Kelly, Mark Mangkhalakhili et al.
Science Translational Medicine
FAQs
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Reconstitution Buffers
Secondary Antibodies
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