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C26-A6

Catalog #: 7692 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7692/10
7692/50
C26-A6 | CAS No. 1341030-00-9 | Cell Adhesion Inhibitors
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Description: Disrupts MTDH and SND1 interaction, enhances immune surveillance

Chemical Name: 5-Chloro-2-methoxy-N-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-8-yl)benzenesulfonamide

Purity: ≥98%

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Biological Activity

C26-A2 inhibits the interaction between MTDH and SND1 by blocking the SND1 pocket. C26-A2 disrupts MTDH-SND1 complex-induced reduction in tumor antigen presentation and T cell infiltration; enhancing immune surveillance and sensitivity to anti-PD-1 therapy in metastatic breast cancer mouse models. C26-A6 suppresses tumor growth (IC50 = 12.3 μM) and metastasis and enhances chemotherapy sensitivity in triple-negative breast cancer (TNBC) mouse models.

Technical Data

M.Wt:
352.79
Formula:
C14H13ClN4O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1341030-00-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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