Caerulein
Purity: ≥95%
Biological Activity
Caerulein is a CCK agonist. Stimulates biosynthesis of pancreatic enzymes in AR4-2J pancreatic cells in vitro. Induces acute pancreatitis in mice. Also enhances proteasome activity in Gdeg mice.Technical Data
(Modifications: X = Glp, Tyr-4 = Tyr(SO3H), Phe-10 = C-terminal amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Yes-associated protein mediates immune reprogramming in pancreatic ductal adenocarcinoma.
Murakami et al.
Oncogene, 2017;36:1232 -
Proteasome activity is required for the initiation of precancerous pancreatic lesions.
Furuyama et al.
Sci.Rep., 2016;6:27044 -
Caerulein and gastrin(2-17 ds) regulate differently synthesis of secretory enzymes, mRNA levels and cell proliferation in pancreatic acinar cells (AR4-2J).
Pradel et al.
Biochem.J., 1993;290:219
Product Datasheets
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Citations for Caerulein
The citations listed below are publications that use Tocris products. Selected citations for Caerulein include:
3 Citations: Showing 1 - 3
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A microRNA checkpoint for Ca2+ signaling and overload in acute pancreatitis.
Authors: Xiaofeng Et al.
Mol Ther 2022;30:1754-1774
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Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis through reducing neutrophil infiltration.
Authors: Li Et al.
Microbiome 2021;9:115
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TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation.
Authors: Stephen J Et al.
J Clin Invest 2020;130:2527-2541
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