Calcipotriol

Biological Activity

Calcipotriol is a vitamin D₃ analog that displays minimal effects on calcium homeostasis. Regulates cell differentiation and proliferation; exhibits antiproliferative activity against human HL-60, HL60/MX2, keratinocytes, MCF-7, T47D, SCC-25, and mouse WEHI-3 cancer cell lines. Calcipotriol suppresses skin cancer development in mice in a thymic stromal lymphopoietin (TSLP)-dependent manner. Calcipotriol promotes the differentiation of keratinocytes. In human T cells and in psoriatic skin, Calcipotriol increases IL-10 secretion, induces secretion of type 2 cytokines by T cells and modulates the differentiation of dendritic cells and T cells.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Comparison of calcipotriol with selected metabolites and analogues of vitamin D₃: effects on cell growth regulation in vitro and calcium metabolism in vivo.
   Binderu
   Pharmacol.Toxicol., 1993;72:240
2. Pharmacokinetics and systemic effect on calcium homeostasis of 1α,24-dihydroxyvitamin D₂ in rats.
   Knutson et al.
   Biochem.Pharmacol., 1997;53:829
3. Antitumor properties of diastereomeric and geometric analogs of vitamin D3.
   Wietrzyk et al.
   Anticancer Drugs, 2007;18:447
4. Periostin Activation of Integrin Receptors on Sensory Neurons Induces Allergic Itch
   SK Mishra, JJ Wheeler, S Pitake, H Ding, C Jiang, T Fukuyama, JS Paps, P Ralph, J Coyne, M Parkington, J DeBrecht, LC Ehrhardt-H, GP Cruse, W Bäumer, RR Ji, MC Ko, T Olivry
   Cell Rep, 2020;31(1):107472.

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