CATPB
Chemical Name: (S)-3-(2-(3-Chlorophenyl)acetamido)-4-(4-(trifluoromethyl)phenyl)butanoic acid
Purity: ≥98%
Biological Activity
CATPB is a FFA2 inverse agonist (pKi = 7.87). Selective for human over mouse FFA2. Increases forskolin-induced cAMP production and inhibits acetate-induced MAPK signaling in cells expressing human FFA2.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Selective novel inverse agonists for human GPR43 augment GLP-1 secretion.
Park et al.
Eur.J.Pharmacol., 2016;771:1 -
Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands.
Sergeev et al.
J.Biol.Chem., 2016;291:303
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