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CCG 1423

Catalog #: 5233
4 Citations Datasheet / COA / SDS

Discontinued Product

5233 has been discontinued.
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CCG 1423 | CAS No. 285986-88-1 | Rho GTPase Inhibitors
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Description: Rho/SRF pathway inhibitor; induces intermediate mesoderm differentiation from ESCs

Chemical Name: N-[2-[(4-Chlorophenyl)amino]-1-methyl-2-oxoethoxy]-3,5-bis(trifluoromethyl)benzamide

Purity: ≥99%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CCG 1423 is a Rho/SRF pathway inhibitor; stimulates apoptosis of a melanoma cell line overexpressing RhoC (A375M2). Suppresses Rho-dependent invasion of PC-3 prostate cancer cells in vitro and inhibits lysophosphatidic acid-induced DNA synthesis in PC-3 prostate cancer cells. When used in combination with Retinoic acid, LY 294002 and Pyridone 6, it induces intermediate mesoderm differentiation from ESCs.

Technical Data

M.Wt:
454.75
Formula:
C18H13ClF6N2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
285986-88-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for CCG 1423

The citations listed below are publications that use Tocris products. Selected citations for CCG 1423 include:

4 Citations: Showing 1 - 4

  1. Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3.
    Authors: Aarthi Et al.
    Viruses  2021;13
  2. Cell Type Dependent Suppression of Inflammatory Mediators by Myocardin Related Transcription Factors.
    Authors: Li Et al.
    Front Physiol  2021;12:732564
  3. Regulation of the Muscarinic M3 Receptor by Myocardin-Related Transcription Factors.
    Authors: Li Et al.
    Front Physiol  2021;12:710968
  4. Narciclasine, an isocarbostyril alkaloid, has preferential activity against primary effusion lymphoma.
    Authors: Preet M Et al.
    Sci Rep  2020;10:5712

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