Home / Retinoic Acid Receptor Agonists / CD 1530

CD 1530

Catalog #: 2554
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2554/10
2554/50
CD 1530 | CAS No. 107430-66-0 | Retinoic Acid Receptor Agonists
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Description: Potent and selective RARγ agonist

Chemical Name: 4-(6-Hydroxy-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoic acid

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CD 1530 is a potent and selective RARγ receptor agonist (Ki values are 150, 1500 and 2750 nM for RARγ, RARβ and RARα receptors respectively). Activates transcriptional activity (AC50 = 1.8 nM).

Technical Data

M.Wt:
398.49
Formula:
C27H26O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
107430-66-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Therapeutic applications for ligands of retinoid receptors.
    Thacher et al.
    Curr.Pharmaceut.Des., 2000;6:25
  2. Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid.
    Maha El Shahawy, Claes-Göran Reibring, Cynthia L Neben, Kristina Hallberg, Pauline Marangoni, Brian D Harfe, Ophir D Klein, Anders Linde, Amel Gritli-Li
    PloS Genetics, 2017;0(0):1553-7404.

Product Datasheets

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Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for CD 1530

The citations listed below are publications that use Tocris products. Selected citations for CD 1530 include:

3 Citations: Showing 1 - 3

  1. Retinoic acid receptor regulation of epimorphic and homeostatic regeneration in the axolotl.
    Authors: Nguyen Et al.
    Development  2017;144:601
  2. Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System afterOptic Nerve Injury
    Authors: Duprey-Díaz Et al.
    PLoS One  2016;11:e0162626
  3. Rargb regulates organ laterality in a zebrafish model of right atrial isomerism.
    Authors: Garnaas Et al.
    Dev Biol  2012;372:178

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