CD 437
Chemical Name: 6-(4-Hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)-2-naphthalenecarboxylic acid
Purity: ≥98%
Biological Activity
CD 437 is a synthetic retinoid that is an RARγ-selective agonist. Displays RARγ-dependent and -independent effects on differentiation and apoptosis.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations
JH Lee, SI Protze, Z Laksman, PH Backx, GM Keller
Cell Stem Cell, 2017;21(2):179-194.e4. -
Rapid and efficient reprogramming of somatic cells to induced pluripotent stem cells by retinoic acid receptor gamma and liver receptor homolog 1.
Wang et al.
Proc.Natl.Acad.Sci.U.S.A., 2011;108:18283 -
The apoptotic action of the retinoid CD437/AHPN: diverse effects, common basis.
Zhao and Spanjaard
J.Biomed.Sci., 2003;10:44
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citations for CD 437
The citations listed below are publications that use Tocris products. Selected citations for CD 437 include:
4 Citations: Showing 1 - 4
-
Perturbational Gene-Expression Signatures for Combinatorial Drug Discovery.
Authors: Huang Et al.
iScience 2019;15:291
-
Human Pluripotent Stem Cell-Derived Atrial and Ventricular Cardiomyocytes Develop from Distinct Mesoderm Populations.
Authors: Lee Et al.
Cell Stem Cell 2017;21:179
-
Retinoic acid receptor gamma impacts cellular adhesion, Alpha5 Beta1 integrin expression and proliferation in K562 cells.
Authors: Kelley
PLoS One 2017;12(5):e0178116
-
Activation of RARα induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity.
Authors: Brigger Et al.
J Neurosci 2015;6:e1861
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for CD 437
There are currently no reviews for this product. Be the first to review CD 437 and earn rewards!
Have you used CD 437?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
