Celastrol
Chemical Name: (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid
Purity: ≥99%
Biological Activity
Celastrol is an antioxidant, anti-inflammatory, antitumor and neuroprotective agent. Inhibits lipid peroxidation in mitochondria, TNF-α-induced NFκB activation, peroxidase activity of peroxiredoxin 1 (IC50 = 0.29 μM), and topoisomerase II activity in vitro (IC50 = 7.41 μM). Celastrol treatment inhibits the growth of PC-3 tumors in mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Metabolic origins of spatial organization in the tumor microenvironment
C Carmona-Fo, M Deforet, L Akkari, CB Thompson, JA Joyce, JB Xavier
Proc. Natl. Acad. Sci. U.S.A, 2017;0(0):. -
Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol.
Nagase et al.
Biosci.Biotechnol.Biochem., 2003;67:1883 -
Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB-regulated gene products and TAK1-mediated NF-κB activation.
Sethi et al.
Blood, 2007;109:2727
Product Datasheets
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Citation for Celastrol
The citations listed below are publications that use Tocris products. Selected citations for Celastrol include:
1 Citation: Showing 1 - 1
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Interleukin 34: a new modulator of human and experimental inflammatory bowel disease.
Authors: Zwicker Et al.
Clin Sci (Lond) 2015;129:281
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