Centrinone B

Catalog #: 5690
8 Citations Datasheet / COA / SDS

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5690/10

Centrinone B | CAS No. 1798871-31-4 | Polo-like Kinase Inhibitors

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Description: High affinity and selective PLK4 inhibitor

Alternative Names: LCR 323

Chemical Name: 2-[[2-Fluoro-4-[[(2-fluoro-3-nitrophenyl)methyl]sulfonyl]phenyl]thio]-5-methoxy-N-(5-methyl-1H-pyrazol-3-yl)-6-(1-piperidinyl)-4-pyrimidinamine

Purity: ≥98%

View All Products for Polo-like Kinase Inhibitors

Product Details

Citations (8)

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

Centrinone B is a high affinity and selective PLK4 inhibitor (K_i = 0.6 nM). Exhibits >2000-fold selectivity for PLK4 over Aurora A and Aurora B. Depletes centriole and centrosome levels in vitro. Induces cell cycle arrest in normal human cell lines in a p53-dependent manner.

Technical Data

M.Wt:

631.67

Formula:

C₂₇H₂₇F₂N₇O₅S₂

Solubility:

Soluble to 50 mM in DMSO

Purity:

≥98%

Storage:

Store at -20°C

CAS No:

1798871-31-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold with the permission of the Ludwig Institute for Cancer Research Ltd

Background References

Reversible centriole depletion with an inhibitor of Polo-like kinase 4.
Wong et al.
Science, 2015;348:1155

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Citations for Centrinone B

The citations listed below are publications that use Tocris products. Selected citations for Centrinone B include:

8 Citations: Showing 1 - 8

Centrosome function is critical during terminal erythroid differentiation.
Authors: Péter Et al.
EMBO J 2022;41:e108739
Investigating the mechanisms of peritoneal metastasis in gastric adenocarcinoma using a novel ex vivo peritoneal explant model.
Authors: Carol J Et al.
Sci Rep 2022;12:11499
Centriole and Golgi microtubule nucleation are dispensable for the migration of human neutrophil-like cells.
Authors: Anna Et al.
Mol Biol Cell 2021;32:1545-1556
FAM46C/TENT5C functions as a tumor suppressor through inhibition of Plk4 activity.
Authors: Minji Et al.
Commun Biol 2020;3:448
Prolonged mitosis results in structurally aberrant and over-elongated centrioles.
Authors: Dong Et al.
J Cell Biol 2020;219
High-Complexity shRNA Libraries and PI3 Kinase Inhibition in Cancer: High-Fidelity Synthetic Lethality Predictions.
Authors: Mues Et al.
Cell Rep 2019;27:631
Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles.
Authors: Chen Et al.
Nat Commun 2017;8:247
Plk4 Promotes Cancer Invasion and Metastasis through Arp2/3 Complex Regulation of the Actin Cytoskeleton.
Authors: Kazazian Et al.
Cancer Res 2017;77:434

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