Ceritinib

Catalog #: 6905 Datasheet / COA / SDS

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Ceritinib | CAS No. 1032900-25-6 | ALK Inhibitors

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Description: Highly potent ALK inhibitor; also potently inhibits IR, IGF1R, STK22D and FLT3

Alternative Names: LDK378

Chemical Name: 5-Chloro-N⁴-[2-[(1-methylethyl)sulfonyl]phenyl]-N²-[5-methyl-2-(1-methylethoxy)-4-(4-piperidinyl)phenyl]-2,4-pyrimidinediamine

Purity: ≥98%

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Biological Activity

Ceritinib is a highly potent anaplastic lymphoma kinase (ALK) inhibitor (IC₅₀ = 0.2 nM). Also displays potent inhibition of insulin receptor (IR), insulin-like growth factor receptor 1 (IGF1R), serine/threonine-protein kinase STK22D and FLT3 (IC₅₀ values are 7, 8, 23 and 60 nM, respectively). Inhibits tumor growth in Karpas299 and H2228 rat xenograft models.

Technical Data

M.Wt:

558.14

Formula:

C₂₈H₃₆ClN₅O₃S

Solubility:

Soluble to 5 mM in DMSO with gentle warming and to 5 mM in ethanol with gentle warming

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

1032900-25-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diam
Marsilje et al.
J.Med.Chem., 2013;56:5675

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