Home / Brutons Tyrosine Kinase (BTK) Inhibitors / CGI 1746

CGI 1746

Catalog #: 6965 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6965/50
6965/10
CGI 1746 | CAS No. 910232-84-7 | Brutons Tyrosine Kinase (BTK) Inhibitors
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Description: Potent, reversible BTK inhibitor

Chemical Name: N-[3-[4,5-Dihydro-4-methyl-6-[[4-(4-morpholinylcarbonyl)phenyl]amino]-5-oxo-2-pyrazinyl]-2-methylphenyl]-4-(1,1-dimethylethyl)benzamide

Purity: ≥97%

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Biological Activity

CGI 1746 is a potent, reversible inhibitor of Bruton's tyrosine kinase (Btk) (IC50 = 1.9 nM). CGI 1746 decreases cell survival in prostate cancer cell lines. In a cell model, CGI 1746 blocks the production of FcγR-induced cytokines IL-1β, TNFα and IL-6 (IC50 values are 36 nM, 47 nM and 353 nM, respectively).

Technical Data

M.Wt:
579.7
Formula:
C34H37N5O4
Solubility:
Soluble to 20 mM in ethanol and to 5 mM in DMSO
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
910232-84-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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