CGP 37157
Chemical Name: 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
Purity: ≥99%
Biological Activity
CGP 37157 is a selective antagonist of the mitochondrial Na+/Ca2+ exchanger (NCX; IC50 = 0.4 μM).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root ganglion neurons.
Baron and Thayer
Eur.J.Pharmacol., 1997;340:295 -
Selectivity of inhibition of Na+-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157.
Cox et al.
J.Cardiovasc.Pharmacol., 1993;21:595 -
Modulation of intramitochondrial free Ca2+ concentration by antagonists of Na+-Ca2+ exchange.
Cox and Matlib
TiPS, 1993;14:408 -
Mitochondria accumulate Ca2+ following intense glutamate stimulation of cultured rat forebrain neurones.
White and Reynolds
J.Physiol., 1997;498:31
Product Datasheets
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Citations for CGP 37157
The citations listed below are publications that use Tocris products. Selected citations for CGP 37157 include:
13 Citations: Showing 1 - 10
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Paraneoplastic cerebellar degeneration: Yo antibody alters mitochondrial calcium buffering capacity.
Authors: Panja Et al.
Neuropathol Appl Neurobiol 2019;45:141
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Selective inhibition of mitochondrial sodium-calcium exchanger protects striatal neurons from α-synuclein plus rotenone induced toxicity.
Authors: Bastioli Et al.
Cell Death Dis 2019;10:80
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Mitochondrial Ca2+ and membrane potential, an alternative pathway for Interleukin 6 to regulate CD4 cell effector function.
Authors: Yang Et al.
J Biol Chem 2015;4
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Routes of Ca2+ Shuttling during Ca2+ Oscillations: FOCUS ON THE ROLE OF MITOCHONDRIAL Ca2+ HANDLING AND CYTOSOLIC Ca2+ BUFFERS.
Authors: Pecze Et al.
World J Gastroenterol 2015;290:28214
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Palmitoylethanolamide inhibits glutamate release in rat cerebrocortical nerve terminals.
Authors: Lin Et al.
Elife 2015;16:5555
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Dynamic buffering of mitochondrial Ca2+ during Ca2+ uptake and Na+-induced Ca2+ release.
Authors: Blomeyer Et al.
J Bioenerg Biomembr 2013;45:189
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Na delivery and ENaC mediate flow regulation of collecting duct endothelin-1 production.
Authors: Pandit Et al.
Am J Physiol Renal Physiol 2012;302:F1325
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Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways.
Authors: Midkiff Et al.
PLoS One 2011;6:e25395
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Bafilomycin A1 activates respiration of neuronal cells via uncoupling associated with flickering depolarization of mitochondria.
Authors: Zhdanov Et al.
Cell Mol Life Sci 2011;68:903
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Target cell-specific involvement of presynaptic mitochondria in post-tetanic potentiation at hippocampal mossy fiber synapses.
Authors: Lee Et al.
J Neurosci 2007;27:13603
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Involvement of mitochondrial Na+-Ca2+ exchange in intestinal pacemaking activity.
Authors: Kim Et al.
J Biol Chem 2006;12:796
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Na+-dependent sources of intra-axonal Ca2+ release in rat optic nerve during in vitro chemical ischemia.
Authors: Nikolaeva Et al.
J Neurosci 2005;25:9960
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Brain mitochondria are primed by moderate Ca2+ rise upon hypoxia/reoxygenation for functional breakdown and morphological disintegration.
Authors: Schild Et al.
Am J Physiol Heart Circ Physiol 2003;278:25454
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