Home / Additional Angiotensin AT2 Receptor Peptides / CGP 42112

CGP 42112

Catalog #: 2569
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2569/1
CGP 42112
1 Image
Description: Selective, high affinity AT2 ligand

Purity: ≥95%

Product Details
Citations (3)
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Biological Activity

CGP 42112 is a selective, high affinity angiotensin AT2 receptor ligand (Ki = 0.24 nM). Displays agonistic properties at proximal tubule AT2 receptors, causes Na+, K+-ATPase inhibition and sodium excretion. Antagonizes Ang-II induced contractions in rabbit aortic rings (IC50 = 1850 nM).

Technical Data

M.Wt:
1052.2
Formula:
C52H69N13O11
Sequence:
YKHPI

(Modifications: Tyr-1 = N-α-Nicotinoyl, Lys-2 = Lys-(N-α-Z-Arg))

Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
127060-75-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Angiotensin II type 2 receptor correlates with therapeutic effects of losartan in rats with adjuvant-induced arthritis.
    Wang D, Hu S, Zhu J, Yuan J, Wu J, Zhou A, Wu Y, Zhao W, Huang Q, Chang Y, Wang Q, Sun W, Wei W
    J Cell Mol Med, 2013;17(12):1577-87.
  2. The role of angiotensin receptor subtypes in cerebrovascular regulation in the rat.
    Naveri
    Acta.Physiol.Scand.Suppl., 1995;630:1
  3. Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway.
    Hakam and Hussain
    Am.J.Physiol.Renal Physiol., 2006;290:F1430
  4. Binding characteristics and vascular effects of various angiotensin II antagonists.
    Criscione et al.
    J.Cardiovas.Pharmacol., 1990;16:S56

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Citations for CGP 42112

The citations listed below are publications that use Tocris products. Selected citations for CGP 42112 include:

3 Citations: Showing 1 - 3

  1. Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats
    Authors: Raffai Et al.
    Journal of Vascular Research  2016;53:105
  2. Perinatal nicotine exposure increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of angiotensin II receptors.
    Authors: Li Et al.
    BMC Cancer  2012;43:2483
  3. Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress.
    Authors: Nostramo Et al.
    Stroke  2012;215:291

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