Charybdotoxin
Discontinued Product
Biological Activity
Charybdotoxin is a specific inhibitor of the big conductance Ca2+-activated K+ channel.Technical Data
(Modifications: X-1 = Glp, Disulfide bridge between 7 - 28, 13 - 33,17 - 35, Ser-37 = C-terminal OH)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain.
Thompson J, Ji G, Neugebauer V
Mol Pain, 2015;11(0):51. -
Charybdotoxin-sensitive K+ channels regulate the myogenic tone in the resting state of arteries from spontaneously hypertensive rats.
Asano et al.
Br.J.Pharmacol., 1993;108:214 -
Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium activated potassium channels.
Gimenez-Gallego et al.
Proc.Natl.Acad.Sci.U.S.A., 1988;85:3329 -
Charybdotoxin, a protein inhibitor of single Ca2+ activated K+ channels from mammalian skeletal muscle.
Miller et al.
Nature, 1985;313:316
Product Datasheets
Citations for Charybdotoxin
The citations listed below are publications that use Tocris products. Selected citations for Charybdotoxin include:
6 Citations: Showing 1 - 6
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Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available R.zole in a rat model of arthritis pain.
Authors: Thompson Et al.
BMC Dermatol 2015;11:51
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Enhanced K(+) secretion in dextran sulfate-induced colitis reflects upregulation of large conductance apical K(+) channels (BK; Kcnma1).
Authors: Kanthesh Et al.
Am J Physiol Cell Physiol 2013;305:C972
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Slo1 is the principal potassium channel of human spermatozoa.
Authors: Mannowetz Et al.
Elife (Cambridge) 2013;2:e01009
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The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea.
Authors: Pulkkinen Et al.
Am J Physiol Lung Cell Mol Physiol 2012;303:L956
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Involvement of dominant-negative spliced variants of the intermediate conductance Ca2+-activated K+ channel, K(Ca)3.1, in immune function of lymphoid cells.
Authors: Ohya Et al.
J Biol Chem 2011;286:16940
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Calcium and Vitamin D increase mRNA levels for the growth control hIK1 channel in human epidermal keratinocytes but functional channels are not observed.
Authors: Manaves Et al.
Sci Rep 2004;4:7
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