CHC
Chemical Name: 2-Cyano-3-(4-hydroxyphenyl)-2-propenoic acid
Purity: ≥98%
Biological Activity
CHC is a monocarboxylic acid transport (MCT) inhibitor. Exhibits antitumoral and antiangiogenic activity in gliomas in vivo; decreases glycolytic metabolism, migration, and invasion in U251 cells. Enhances the effect of antitumor agent temozolomide (Cat No. 2706). Blocks lactate efflux from glioma cells and sensitizes cells to irradiation.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Metabolic remodeling of malignant gliomas for enhanced sensitization during radiotherapy: an in vitro study.
Colen et al.
Neurosurgery, 2006;59:1313 -
Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets.
Miranda-Gonçalves et al.
Neuro.Oncol., 2013;15:172 -
The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma.
Fang et al.
Mol.Pharmacol., 2006;70:2108 -
The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells.
Dimmer et al.
Biochem.J., 2000;350:219
Product Datasheets
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Citations for CHC
The citations listed below are publications that use Tocris products. Selected citations for CHC include:
5 Citations: Showing 1 - 5
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Amyloid-β42 stimulated hippocampal lactate release is coupled to glutamate uptake.
Authors: Kevin N Et al.
Sci Rep 2022;12:2775
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MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages.
Authors: Kelvin P Et al.
Cell Rep 2021;35:109264
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A glycolytic shift in Schwann cells supports injured axons.
Authors: Keit Men Et al.
Nat Neurosci 2020;23:1215-1228
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Metformin and LW6 impairs pancreatic cancer cells and reduces nuclear localization of YAP1.
Authors: Dietmar Et al.
J Cancer 2020;11:479-487
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A branched-chain amino acid metabolite drives vascular fatty acid transport and causes Ins resistance.
Authors: Jang Et al.
Nat Med 2016;22:421
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