CHDI 00580985 New
Chemical Name: (2R)-4-(3-Fluoro-4-pyridinyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]-2-methyl-1-piperazinecarboxamide
Purity: ≥98%
Biological Activity
CHDI 00580985 is a potent and selective ROCK inhibitor (IC50 values are 3 nM and 8 nM in biochemical (ROCK2) and cellular assays respectively). CHDI 00580985 inhibits ROCK-mediated substrate (MYPT1) phosphorylation (IC50 = 4 nM). In vivo, CHDI 00580985 reduces ROCK signaling in Huntington's disease mouse models in pharmacodynamic assay. CHDI 00580985 is bioavailable and brain penetrant.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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