Chemerin-9, Human
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Description: Potent CMKLR1 agonist; c-terminal peptide of full length human chemerin
Purity: ≥95%
Biological Activity
Chemerin-9, Human is a potent chemokine-like receptor 1 (CMKLR1; also known as chemerin receptor 23, ChemR23) agonist (EC50 = 7.1 nM at CMKLR expressed in CHO cells). Corresponds to C-terminal of full length human Chemerin, amino acids 149 - 157. Activates Gi/o signaling pathways in vitro; inhibits cAMP production and promotes phospholipase C production and Ca2+ mobilization.Technical Data
M.Wt:
1063.18
Formula:
C54H66N10O13
Sequence:
YFPGQFAFS
Solubility:
Soluble to 1 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
676367-27-4
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency.
Wittamer et al.
J.Med.Chem., 2004;279:9956 -
Signaling properties of chemerin receptors CMKLR1, GPR1 and CCRL2.
De Henau et al.
PLoS One., 2016;11
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