CHIR 99021 trihydrochloride

Catalog # Availability Size / Price Qty
4953/10
4953/50
CHIR 99021 trihydrochloride | CAS No. 1782235-14-6 | GSK-3 Inhibitors
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Description: Hydrochloride salt of CHIR 99021 (Cat. No. 4423); selective GSK-3 inhibitor
Alternative Names: CT99021

Chemical Name: 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile trihydrochloride

Purity: ≥98%

Product Details
Citations (19)
Supplemental Products
Reviews

Biological Activity

CHIR 99021 trihydrochloride is a hydrochloride salt of CHIR 99021 (Cat. No. 4423), a highly selective GSK-3 inhibitor.

CHIR 99021, CHIR 99021 in solution and CHIR 99021 synthesized to cGMP guidelines also available.

External Portal Information

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of CHIR 99021 is reviewed on the chemical probes website.

Technical Data

M.Wt:
574.72
Formula:
C22H18Cl2N8.3HCl
Solubility:
Soluble to 25 mM in water and to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1782235-14-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for CHIR 99021 trihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for CHIR 99021 trihydrochloride include:

19 Citations: Showing 1 - 10

  1. Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from induced pluripotent stem cells.
    Authors: Yasuhiro Et al.
    Cell Rep Methods  2023;3:100460
  2. Generation and characterization of NGLY1 patient-derived midbrain organoids.
    Authors: Wei Et al.
    Front Cell Dev Biol  2023;11:1039182
  3. Single-cell sequencing reveals lineage-specific dynamic genetic regulation of gene expression during human cardiomyocyte differentiation.
    Authors: Guanghao Et al.
    PLoS Genet  2022;18:e1009666
  4. Selective activation and down-regulation of Trk receptors by neurotrophins in human neurons co-expressing TrkB and TrkC.
    Authors: Jia Et al.
    J Neurochem  2022;161:463-477
  5. Naïve-like pluripotency to pave the way for saving the northern white rhinoceros from extinction.
    Authors: Dmitry Et al.
    Sci Rep  2022;12:3100
  6. Human spinal cord in vitro differentiation pace is initially maintained in heterologous embryonic environments.
    Authors: Kate G Et al.
    Elife  2022;11
  7. Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids.
    Authors: Ling Et al.
    Cell Stem Cell  2021;28:1090-1104.e6
  8. Autologous transplant therapy alleviates motor and depressive behaviors in parkinsonian monkeys.
    Authors: Viktoriya Et al.
    Nat Med  2021;27:632-639
  9. Non-invasive and high-throughput interrogation of exon-specific isoform expression.
    Authors: Peter Et al.
    Nat Cell Biol  2021;23:652-663
  10. Single-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes.
    Authors: Benjamin Et al.
    Nat Commun  2021;12:4203

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