CHPG
1 Image
Description: mGlu5 selective agonist
Chemical Name: (RS)-2-Chloro-5-hydroxyphenylglycine
Purity: ≥99%
Biological Activity
CHPG is a selective mGlu5 metabotropic glutamate receptor agonist, completely inactive at mGlu1a receptors expressed in CHO cells. Active in vivo.Sodium Salt also available.
Technical Data
M.Wt:
201.61
Formula:
C8H8NO3Cl
Solubility:
Soluble to 100 mM in 1.1eq. NaOH
Purity:
≥99%
Storage:
Store at RT
CAS No:
170846-74-9
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Other Product-Specific Information:
Background References
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Anticonvulsive effect of paeoniflorin on experimental febrile seizures in immature rats: possible application for febrile seizures in children.
Hino H, Takahashi H, Suzuki Y, Tanaka J, Ishii E, Fukuda M
PLoS ONE, 2012;7(8):e42920. -
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
(RS)-2-Chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlu1, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus.
Doherty et al.
Neuropharmacology, 1997;36:265 -
Antagonism of the mGlu5 agonist 2-chloro-5-hydroxyphenylglycine by the novel selective mGlu5 antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) in the thalamus.
Salt et al.
Br.J.Pharmacol., 1999;127:1057 -
Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischaemia.
Bao et al.
Brain Res., 2001;922:173 -
Potentiation of NMDA and AMPA responses by the specific mGluR5 agonist CHPG in spinal cord motoneurones.
Ugolini et al.
Neuropharmacology, 1999;38:1569
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Citations for CHPG
The citations listed below are publications that use Tocris products. Selected citations for CHPG include:
17 Citations: Showing 1 - 10
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The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex.
Authors: David-Pereira
Neuroscience 2017;349:341
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Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
Authors: Tang Et al.
J Neurosci 2015;35:3016
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Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors.
Authors: Rojas Et al.
Mol Pharmacol 2013;83:106
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Activation of mGluR5 and inhibition of NADPH oxidase improves functional recovery after traumatic brain injury.
Authors: Loane Et al.
J Biol Chem 2013;30:403
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Metabotropic glutamate receptor 5 contributes to inflammatory tongue pain via extracellular signal-regulated kinase signaling in the trigeminal spinal subnucleus caudalis and upper cervical spinal cord.
Authors: Liu Et al.
J Neuroinflammation 2012;9:258
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Anticonvulsive effect of paeoniflorin on experimental febrile seizures in immature rats: possible application for febrile seizures in children.
Authors: Hino Et al.
PLoS One 2012;7:e42920
-
Metabotropic glutamate receptor 5 mediates phosphorylation of vascular endothelial cadherin and nuclear localization of β-catenin in response to homocysteine.
Authors: Beard Et al.
Vascul Pharmacol 2012;56:159
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The orthosteric agonist 2-chloro-5-hydroxyphenylglycine activates mGluR5 and mGluR1 with similar efficacy and potency.
Authors: Kammermeier
Proc Natl Acad Sci U S A 2012;12:6
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Intrathecal injection of metabotropic glutamate receptor subtype 3 and 5 agonist/antagonist attenuates bone cancer pain by inhibition of spinal astrocyte activation in a mouse model.
Authors: Ren Et al.
Anesthesiology 2012;116:122
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mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway.
Authors: Chen Et al.
J Biomed Sci 2011;18:19
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Sensory and cortical activation of distinct glial cell subtypes in the somatosensory thalamus of young rats.
Authors: Parri Et al.
Eur J Neurosci 2010;32:29
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Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents.
Authors: Byrnes Et al.
Ann Neurol 2009;66:63
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Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity.
Authors: Byrnes Et al.
J Neurotrauma 2009;57:550
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Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain.
Authors: Lin Et al.
J Biomed Sci 2009;16:94
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Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.
Authors: Neyman and Manahan-Vaughan
Eur J Neurosci 2008;27:1345
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Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome.
Authors: Kim Et al.
BMC Pharmacol 2008;105:4429
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Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function.
Authors: Ferré Et al.
Glia 2002;99:11940
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