Home / Integrin Receptor Inhibitors / Cilengitide

Cilengitide

Catalog #: 5870
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5870/10
Cilengitide
1 Image
Description: Potent and selective inhibitor of integrins αvβ3 and αvβ5
Alternative Names: EMD121974

Purity: ≥95%

Product Details
Citations (6)
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Biological Activity

Cilengitide is a potent and selective inhibitor of integrins αvβ3 and αvβ5 (IC50 values are 4.1 and 70 nM, respectively). Exhibits ~10-fold selectivity over gpIIb/IIIa. Increases endothelial monolayer permeability. Also exhibits antiangiogenic activity.

Technical Data

M.Wt:
588.66
Formula:
C27H40N8O7
Sequence:
RGDFV

(Modifications: Phe-4 = D-Phe, Val-5 = Me-Val, Cyclized)

Solubility:
Soluble to 10 mg/ml in water
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
188968-51-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Cilengitide

The citations listed below are publications that use Tocris products. Selected citations for Cilengitide include:

6 Citations: Showing 1 - 6

  1. Integrins Bidirectionally Regulate the Efficacy of Inhibitory Synaptic Transmission and Control GABAergic Plasticity.
    Authors: Jerzy W Et al.
    J Neurosci  2022;42:5830-5842
  2. G protein-coupled receptor kinase phosphorylation of distal C-tail sites specifies βarrestin1-mediated signaling by chemokine receptor CXCR4.
    Authors: Adriano Et al.
    J Biol Chem  2022;298:102351
  3. Extracorporeal shock waves protect cardiomyocytes from DOX-induced cardiomyopathy by upregulating survivin via the integrin-ILK-Akt-Sp1/p53 axis.
    Authors: Lee Et al.
    Sci Rep  2019;9:12149
  4. Activation of αvβ3 Integrin Alters Fibronectin Fibril Formation in Human Trabecular Meshwork Cells in a ROCK-Independent Manner.
    Authors: Filla Et al.
    Invest Ophthalmol Vis Sci  2019;60:3897
  5. Subendothelial matrix components influence endothelial cell apoptosis in vitro.
    Authors: Elazer R Et al.
    Am J Physiol Cell Physiol  2019;316:C210-C222
  6. Piezo1 and Gq/G11 promote endothelial inflammation depending on flow pattern and integrin activation.
    Authors: Albarrán-Juárez Et al.
    J Exp Med  2018;215:2655

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