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CL 82198 hydrochloride

Catalog #: 2632
3 Citations Datasheet / COA / SDS
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2632/10
2632/50
CL 82198 hydrochloride | CAS No. 1188890-36-9 | Synthetic Metalloprotease Inhibitors
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Description: Selective inhibitor of MMP-13

Chemical Name: N-[4-(4-Morpholinyl)butyl]-2-benzofurancarboxamide hydrochloride

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

CL 82198 hydrochloride is a selective inhibitor of MMP-13 (89% inhibition at 10 μg/mL) that displays no activity at MMP-1, MMP-9 or TACE. Inhibits in vitro invasion by the human pituitary adenoma cell line HP75. Rescues paclitaxel induced axon degradation and reduces associated neurotoxicity in zebrafish.

Technical Data

M.Wt:
338.83
Formula:
C17H23N2O3.HCl
Solubility:
Soluble to 100 mM in water and to 75 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1188890-36-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Structure-based design of a novel, potent, and selective inhibitor for MMP-13 utilizing NMR spectroscopy and computer-aided molecular design.
    Chen et al.
    J.Am.Chem.Soc., 2000;122:9648
  2. IL1 alpha, IL6 and MMP13 are required for invasion by the human pituitary cell line HP75.
    Borg et al.
    Endocrine Abstr., 2003;5:122
  3. PacT.-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish.
    Lisse et al.
    Proc Natl Acad Sci U S A, 2016;113:E2189

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Citations for CL 82198 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for CL 82198 hydrochloride include:

3 Citations: Showing 1 - 3

  1. PacT.-induced epithelial damage and ectopic MMP-13 expression promotes neurotoxicity in zebrafish.
    Authors: Lisse Et al.
    Proc Natl Acad Sci U S A  2016;113:E2189
  2. MMP13 is a critical target gene during the progression of osteoarthritis.
    Authors: Wang Et al.
    J Neurosci  2013;15:R5
  3. MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation.
    Authors: Meierjohann Et al.
    Mol Cancer  2010;9:201

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