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Clofarabine

Catalog #: 2600
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Clofarabine | CAS No. 123318-82-1 | Kinase Substrates
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Description: Deoxycytidine kinase (dCK) substrate

Chemical Name: 2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine

Purity: ≥99%

Product Details
Citations (1)
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Biological Activity

Clofarabine is a deoxycytidine kinase (dCK) substrate. Phosphorylated to form clofarabine triphosphate, which competes with dATP for DNA polymerase-α and -ε and potently inhibits ribonucleotide reductase (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Demonstrates growth inhibition and cytotoxic activity in a variety of leukemias and solid tumors.

Technical Data

M.Wt:
303.68
Formula:
C10H11ClFN5O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
123318-82-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effects of 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate.
    Parker et al.
    Cancer Res., 1991;51:2386
  2. Discovery and development of clofarabine: a nucleoside analogue for treating cancer.
    Bonate et al.
    Nat.Rev.Drug Discov., 2006;5:855
  3. Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine.
    Carson et al.
    Proc.Natl.Acad.Sci.USA, 1992;89:2970

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Citation for Clofarabine

The citations listed below are publications that use Tocris products. Selected citations for Clofarabine include:

1 Citation: Showing 1 - 1

  1. Valproic acid synergistically enhances the cytotoxicity of clofar. in pediatric acute myeloid leukemia cells.
    Authors: Xie Et al.
    Pediatr Blood Cancer  2012;59:1245

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