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(+)-Clopidogrel hydrogen sulfate

Catalog #: 1820 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1820/10
1820/50
(+)-Clopidogrel hydrogen sulfate | CAS No. 120202-66-6 | P2Y Receptor Antagonists
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Description: Selective P2Y12 antagonist
Alternative Names: Plavix

Chemical Name: (S)-(+)-Methyl 2-(4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl)-2-(2-chlorophenyl)acetate hydrogen sulfate

Purity: ≥99%

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Biological Activity

(+)-Clopidogrel hydrogen sulfate is a selective, high affinity P2Y12 receptor antagonist. Inhibits ADP-induced platelet aggregation and displays antithrombotic activity. Active enantiomer of (±)-clopidogrel hydrochloride (Cat. No. 2490). Requires bioactivation.

Technical Data

M.Wt:
419.9
Formula:
C16H16ClNO2S.H2SO4
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
120202-66-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Effects of GS-9876, a novel spleen tyrosine kinase inhibitor, on platelet function and systemic hemostasis
    AS Clarke, E Rousseau, K Wang, JY Kim, BP Murray, R Bannister, F Matzkies, KS Currie, JA Di Paolo
    Thromb. Res., 2018;170(0):109-118.
  2. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes.
    Kugelgen
    Pharmacol.Ther., 2006;110:415
  3. Clopidogrel and ticlopidine: P2Y12 adenosine diphosphate-receptor antagonists for the prevention of atherothrombosis.
    Savi and Herbert
    Semin.Thromb.Haemostas., 2005;31:174
  4. Very low chiral inversion of clopid. in rats: a pharmacokinetic and mechanistic investigation.
    Reist et al.
    Drug Metab.Disp., 2000;28:1405
  5. P2Y12, a new platelet ADP receptor, target of clopid.
    Savi et al.
    Biochem.Biophys.Res.Comm., 2001;283:379

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