CLP 290
Chemical Name: (Z)-5-Fluoro-2-((4-oxo-2-(tetrahydropyridazin-1(2H)-yl)thiazol-5(4H)-ylidene)methyl)phenyl pyrrolidine-1-carboxylate
Purity: ≥98%
Biological Activity
CLP 290 is a K+/Cl- Cotransporter 2 (KCC2) activator. Activates spinal inhibitory interneurons, restores physiological neuronal activity in the spinal cord and induces functional recovery in a mouse model of spinal cord injury. Also decreases blood vasopressin and glucose levels in mice with Streptozotocin (Cat. No. 1621) induced diabetes mellitus. Orally bioavailable prodrug of CLP 257 (Cat. No.5242).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Chloride extrusion enhancers as novel therapeutics for neurological diseases.
Gagnon et al.
Nat.Med., 2013;19:1524 -
Long-term ionic plasticity of GABAergic signalling in the hypothalamus.
Kim et al.
J.Neuroendocrinol., 2019;31:e12753 -
Reactivation of dormant relay pathways in injured spinal cord by KCC2 manipulations.
Chen et al.
Cell, 2018;174:521
Product Datasheets
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