CometSlide

The N6-methyladenosine methyltransferase METTL16 enables erythropoiesis through safeguarding genome integrity
Authors: M Yoshinaga, K Han, DW Morgens, T Horii, R Kobayashi, T Tsuruyama, F Hia, S Yasukura, A Kajiya, T Cai, PHC Cruz, A Vandenbon, Y Suzuki, Y Kawahara, I Hatada, MC Bassik, O Takeuchi
Nature Communications, 2022-10-28;13(1):6435.  2022-10-28

Targeting DNA repair with combined inhibition of NHEJ and MMEJ induces synthetic lethality in TP53-mutant cancers
Authors: J Patterson-, A Bose, WC Tsai, CJ Grochala, H Nguyen, J Zhou, K Parmar, JB Lazaro, JF Liu, K McQueen, GI Shapiro, D Kozono, AD D'Andrea
Cancer Research, 2022-10-17;0(0):.  2022-10-17

OGG1 Inhibition Reduces Acinar Cell Injury in a Mouse Model of Acute Pancreatitis
Authors: Z Hajnády, M Nagy-Pénze, MA Demény, K Kovács, T El-Hamoly, J Maléth, P Hegyi, Z Polgár, C Heged?s, L Virág
Biomedicines, 2022-10-12;10(10):.  2022-10-12

Efficient bioremediation of laboratory wastewater co-contaminated with PAHs and dimethylformamide by a methylotrophic enrichment culture
Authors: K Dhar, AK Sivaram, L Panneersel, K Venkateswa, M Megharaj
Journal of environmental management, 2022-10-11;325(0):116425.  2022-10-11

Genotoxicity Evaluation of Metformin in Freshwater Planarian Dugesia japonica by the Comet Assay and RAPD Analysis
Authors: D Yin, Z Xu, M Feng, Z Zhao, D Chen, L Song
BioMed Research International, 2022-08-17;2022(0):2822605.  2022-08-17

Exposure of men living in the greater Montreal area to organophosphate esters: Association with hormonal balance and semen quality
Authors: S Siddique, I Farhat, C Kubwabo, P Chan, CG Goodyer, B Robaire, J Chevrier, BF Hales
Environment international, 2022-07-09;166(0):107402.  2022-07-09

Aspalathus linearis suppresses cell survival and proliferation of enzalutamide-resistant prostate cancer cells via inhibition of c-Myc and stability of androgen receptor
Authors: BJ Wang, SH Huang, CL Kao, CJF Muller, YP Wang, KH Chang, HC Wen, CC Yeh, LJ Shih, YH Kao, SP Huang, CY Li, CP Chuu
PLoS ONE, 2022-07-01;17(7):e0270803.  2022-07-01

WASp modulates RPA function on single-stranded DNA in response to replication stress and DNA damage
Authors: SS Han, KK Wen, ML García-Rub, MS Wold, A Aguilera, W Niedzwiedz, YM Vyas
Nature Communications, 2022-06-29;13(1):3743.  2022-06-29

Safety evaluation of carbon tetrafluoride as an inert hyperbaric breathing gas in Sprague-Dawley rats
Authors: MS Makowski, C Sproul, C Swartz, JI Everitt, DA Knaus, JC Wilbur, RE Moon
Toxicology and Applied Pharmacology, 2022-04-13;444(0):116023.  2022-04-13

Mutations of the DNA repair gene PNKP in a patient with microcephaly, seizures, and developmental delay (MCSZ) presenting with a high-grade brain tumor
Authors: B Jiang, C Murray, BL Cole, JNM Glover, GK Chan, J Deschenes, RS Mani, S Subedi, JD Nerva, AC Wang, CM Lockwood, HC Mefford, SES Leary, JG Ojemann, M Weinfeld, CI Ene
Scientific Reports, 2022-03-30;12(1):5386.  2022-03-30

The out-of-field dose in radiation therapy induces delayed tumorigenesis by senescence evasion
Authors: E Goy, M Tomezak, C Facchin, N Martin, E Bouchaert, J Benoit, C de Schutte, J Nassour, L Saas, C Drullion, PM Brodin, A Vandeputte, O Molendi-Co, L Pineau, G Goormachti, O Pluquet, A Pourtier, F Cleri, E Lartigau, N Penel, C Abbadie
Elife, 2022-03-18;11(0):.  2022-03-18

R-loop proximity proteomics identifies a role of DDX41 in transcription-associated genomic instability
Authors: T Mosler, F Conte, GMC Longo, I Mikicic, N Kreim, MM Möckel, G Petrosino, J Flach, J Barau, B Luke, V Roukos, P Beli
Nature Communications, 2021-12-16;12(1):7314.  2021-12-16

The chromatin remodeler RSF1 coordinates epigenetic marks for transcriptional repression and DSB repair
Authors: S Min, HS Lee, JH Ji, Y Heo, Y Kim, S Chae, YW Choi, HC Kang, M Nakanishi, H Cho
Nucleic Acids Research, 2021-12-02;49(21):12268-12283.  2021-12-02

Elp1 facilitates RAD51-mediated homologous recombination repair via translational regulation
Authors: WT Chen, HY Tseng, CL Jiang, CY Lee, P Chi, LY Chen, KY Lo, IC Wang, FJ Lin
Journal of Biomedical Science, 2021-11-24;28(1):81.  2021-11-24

Targeting eIF4F translation complex sensitizes B-ALL cells to tyrosine kinase inhibition
Authors: TT Vo, LO Herzog, R Buono, JS Lee, S Mallya, MR Duong, J Thao, M Gotesman, DA Fruman
Scientific Reports, 2021-11-04;11(1):21689.  2021-11-04

DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model
Authors: SL Paluri, M Burak, AG Senejani, M Levinson, T Rahim, K Clairmont, M Kashgarian, I Alvarado-C, R Meas, M Cardó-Vila, C Zeiss, S Maher, ALM Bothwell, E Coskun, M Kant, P Jaruga, M Dizdaroglu, R Stephen Ll, JB Sweasy
DNA repair, 2021-06-24;105(0):103152.  2021-06-24

A DYRK1B-dependent pathway suppresses rDNA transcription in response to DNA damage
Authors: C Dong, L An, CH Yu, MSY Huen
Nucleic Acids Research, 2021-02-22;0(0):.  2021-02-22

PLA2R1 promotes DNA damage and inhibits spontaneous tumor formation during aging
Authors: A Huna, A Griveau, D Vindrieux, S Jaber, JM Flaman, D Goehrig, L Azzi, JJ Médard, S Djebali, H Hernandez-, R Dante, L Payen, J Marvel, P Bertolino, S Aubert, P Dubus, D Bernard
Cell Death & Disease, 2021-02-16;12(2):190.  2021-02-16

Aldehyde dehydrogenase inhibitors promote DNA damage in ovarian cancer and synergize with ATM/ATR inhibitors
Authors: E Grimley, AJ Cole, TT Luong, SC McGonigal, S Sinno, D Yang, KA Bernstein, RJ Buckanovic
Theranostics, 2021-01-20;11(8):3540-3551.  2021-01-20

Super-resolution visualization of distinct stalled and broken replication fork structures
Authors: DR Whelan, WTC Lee, F Marks, YT Kong, Y Yin, E Rothenberg
PloS Genetics, 2020-12-28;16(12):e1009256.  2020-12-28

Impairment of sirtuin 1-mediated DNA repair is involved in bisphenol A-induced aggravation of macrophage inflammation and atherosclerosis
Authors: Y Yang, C Liu, J Yang, F Yuan, R Cheng, R Chen, Y Shen, L Huang
Chemosphere, 2020-11-18;0(0):128997.  2020-11-18

Deep learning method for comet segmentation and comet assay image analysis
Authors: Y Hong, HJ Han, H Lee, D Lee, J Ko, ZY Hong, JY Lee, JH Seok, HS Lim, WC Son, I Sohn
Sci Rep, 2020-11-03;10(1):18915.  2020-11-03

Alkyladenine DNA glycosylase deficiency uncouples alkylation-induced strand break generation from PARP-1 activation and glycolysis inhibition
Authors: FA Alhumaydhi, D de O Lopes, DL Bordin, ASM Aljohani, CB Lloyd, MD McNicholas, L Milano, CF Charlier, I Villela, JAP Henriques, KE Plant, RM Elliott, LB Meira
Sci Rep, 2020-02-10;10(1):2209.  2020-02-10

Barrier-to-autointegration factor 1 (Banf1) regulates poly [ADP-ribose] polymerase 1 (PARP1) activity following oxidative DNA damage
Authors: E Bolderson, JT Burgess, J Li, NS Gandhi, D Boucher, LV Croft, S Beard, JJ Plowman, A Suraweera, MN Adams, A Naqi, SD Zhang, DA Sinclair, KJ O'Byrne, DJ Richard
Nat Commun, 2019-12-03;10(1):5501.  2019-12-03

Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression
Authors: NP Montaldo, DL Bordin, A Brambilla, M Rösinger, SL Fordyce Ma, KØ Bjørås, S Bradamante, PA Aas, A Furrer, LC Olsen, N Kunath, M Otterlei, P Sætrom, M Bjørås, LD Samson, B van Loon
Nat Commun, 2019-11-29;10(1):5460.  2019-11-29

Inducing and exploiting vulnerabilities for the treatment of liver cancer
Authors: C Wang, S Vegna, H Jin, B Benedict, C Lieftink, C Ramirez, RL de Oliveir, B Morris, J Gadiot, W Wang, A du Chatini, L Wang, D Gao, B Evers, G Jin, Z Xue, A Schepers, F Jochems, AM Sanchez, S Mainardi, H Te Riele, RL Beijersber, W Qin, L Akkari, R Bernards
Nature, 2019-10-02;0(0):.  2019-10-02

Recovery from repeated stressors: Physiology and behavior are affected on different timescales in house sparrows
Authors: BMG Gormally, R Estrada, H Yin, LM Romero
Gen. Comp. Endocrinol., 2019-07-19;282(0):113225.  2019-07-19

Repair-independent functions of DNA-PKcs protect irradiated cells from mitotic slippage and accelerated senescence
Authors: Y Liu, EV Efimova, A Ramamurthy, SJ Kron
J. Cell. Sci., 2019-07-01;132(13):.  2019-07-01

Abnormal leaf development of rpt5a mutant under zinc deficiency reveals important role of DNA damage alleviation for normal leaf development
Authors: N Sotta, T Sakamoto, S Matsunaga, T Fujiwara
Sci Rep, 2019-06-27;9(1):9369.  2019-06-27

Cell line-specific efficacy of thermoradiotherapy in human and canine cancer cells in vitro
Authors: KJ Nytko, P Thumser-He, MS Weyland, S Scheidegge, CR Bley
PLoS ONE, 2019-05-15;14(5):e0216744.  2019-05-15

Phytoremediation efficacy assessment of polycyclic aromatic hydrocarbons contaminated soils using garden pea (Pisum sativum) and earthworms (Eisenia fetida)
Authors: AK Sivaram, P Logeshwara, R Lockington, R Naidu, M Megharaj
Chemosphere, 2019-05-02;229(0):227-235.  2019-05-02

CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs
Authors: M Mohiuddin, MM Rahman, JE Sale, CE Pearson
Nucleic Acids Res., 2019-04-08;0(0):.  2019-04-08

O-GlcNAcylation enhances double strand break repair, promotes cancer cell proliferation and prevents therapy-induced senescence in irradiated tumors
Authors: EV Efimova, OK Appelbe, N Ricco, SS Lee, Y Liu, DJ Wolfgeher, TN Collins, AC Flor, A Ramamurthy, S Warrington, VP Bindokas, SJ Kron
Mol. Cancer Res., 2019-03-18;0(0):.  2019-03-18

PRRX1 isoforms cooperate with FOXM1 to regulate the DNA damage response in pancreatic cancer cells
Authors: B Marchand, JR Pitarresi, M Reichert, K Suzuki, D Laczkó, AK Rustgi
Oncogene, 2019-01-31;0(0):.  2019-01-31

Targeting the lysosome by an aminomethylated Riccardin D triggers DNA damage through cathepsin B-mediated degradation of BRCA1
Authors: Y Wang, H Niu, Z Hu, M Zhu, L Wang, L Han, L Qian, K Tian, H Yuan, H Lou
J. Cell. Mol. Med., 2018-12-18;0(0):.  2018-12-18

Marginal Zinc Deficiency and Environmentally Relevant Concentrations of Arsenic Elicit Combined Effects on the Gut Microbiome
Authors: CA Gaulke, J Rolshoven, CP Wong, LG Hudson, E Ho, TJ Sharpton
mSphere, 2018-12-05;3(6):.  2018-12-05

STAT5A/B BLOCKADE SENSITIZES PROSTATE CANCER TO RADIATION THROUGH INHIBITION OF RAD51 AND DNA REPAIR
Authors: C Maranto, V Udhane, DT Hoang, L Gu, V Alexeev, KM Malas, K Cardenas, JR Brody, U Rodeck, C Bergom, KA Iczkowski, K Jacobsohn, WA See, SM Schmitt, MT Nevalainen
Clin. Cancer Res., 2018-02-26;0(0):.  2018-02-26

B1, a novel HDAC inhibitor, induces apoptosis through the regulation of STAT3 and NF-kappaB.
Authors: Cheng M, Wong Y, Chang C, Yang C, Chen S, Yuan C, Kuo H, Yang C, Chiu H
Int J Mol Med, 2017-04-07;39(5):1137-1148.  2017-04-07

Sexual signals reflect telomere dynamics in a wild bird.
Authors: Taff C, Freeman-Gallant C
Ecol Evol, 2017-04-04;7(10):3436-3442.  2017-04-04

Synthetic beta-nitrostyrene derivative CYT-Rx20 as inhibitor of oral cancer cell proliferation and tumor growth through glutathione suppression and reactive oxygen species induction.
Authors: Wang Y, Chen Y, Hsu Y, Chiu W, Tsai C, Hu S, Hsieh P, Yuan S
Head Neck, 2017-03-27;39(6):1055-1064.  2017-03-27

The GH/IGF-1 axis in a critical period early in life determines cellular DNA repair capacity by altering transcriptional regulation of DNA repair-related genes: implications for the developmental origins of cancer.
Authors: Podlutsky A, Valcarcel-Ares M, Yancey K, Podlutskaya V, Nagykaldi E, Gautam T, Miller R, Sonntag W, Csiszar A, Ungvari Z
Geroscience, 2017-02-23;39(2):147-160.  2017-02-23

FASN regulates cellular response to genotoxic treatments by increasing PARP-1 expression and DNA repair activity via NF-κB and SP1.
Authors: Wu X, Dong Z, Wang C, Barlow L, Fako V, Serrano M, Zou Y, Liu J, Zhang J
Proc Natl Acad Sci U S A, 2016-10-24;0(0):.  2016-10-24

Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.
Authors: Lu E, McLellan M, Ding L, Fulton R, Mardis E, Wilson R, Miller C, Westervelt P, DiPersio J, Link D, Walter M, Ley T, Graubert T
Blood, 2014-10-27;124(26):3887-95.  2014-10-27

Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage.
Authors: Cleaver J, Brennan-Minnella A, Swanson R, Fong K, Chen J, Chou K, Chen Y, Revet I, Bezrookove V
Proc Natl Acad Sci U S A, 2014-08-18;111(37):13487-92.  2014-08-18

Sequential combination therapy of ovarian cancer with degradable N-(2-hydroxypropyl)methacrylamide copolymer paclitaxel and gemcitabine conjugates.
Authors: Zhang R, Yang J, Sima M, Zhou Y, Kopecek J
Proc Natl Acad Sci U S A, 2014-08-04;111(33):12181-6.  2014-08-04

ATM regulates NF-kappaB-dependent immediate-early genes via RelA Ser 276 phosphorylation coupled to CDK9 promoter recruitment.
Authors: Fang L, Choudhary S, Zhao Y, Edeh C, Yang C, Boldogh I, Brasier A
Nucleic Acids Res, 2014-06-23;42(13):8416-32.  2014-06-23

The S229L colon tumor-associated variant of DNA polymerase beta induces cellular transformation as a result of decreased polymerization efficiency.
Authors: Nemec A, Murphy D, Donigan K, Sweasy J
J Biol Chem, 2014-03-25;289(20):13708-16.  2014-03-25

Toxicological profile of small airway epithelial cells exposed to gold nanoparticles.
Authors: Ng C, Li J, Gurung R, Hande M, Ong C, Bay B, Yung L
Exp Biol Med (Maywood), 2013-10-24;238(12):1355-61.  2013-10-24

Validation of freezing tissues and cells for analysis of DNA strand break levels by comet assay.
Authors: Jackson P, Pedersen L, Kyjovska Z, Jacobsen N, Saber A, Hougaard K, Vogel U, Wallin H
Mutagenesis, 2013-10-17;28(6):699-707.  2013-10-17

Intracellular deoxyribonucleotide pool imbalance and DNA damage in cells treated with hydroxyurea, an inhibitor of ribonucleotide reductase.
Authors: Osterman Golkar S, Czene S, Gokarakonda A, Haghdoost S
Mutagenesis, 2013-09-27;28(6):653-60.  2013-09-27

Silencing of human DNA polymerase lambda causes replication stress and is synthetically lethal with an impaired S phase checkpoint.
Authors: Zucca E, Bertoletti F, Wimmer U, Ferrari E, Mazzini G, Khoronenkova S, Grosse N, van Loon B, Dianov G, Hubscher U, Maga G
Nucleic Acids Res, 2012-10-30;41(1):229-41.  2012-10-30

Y265C DNA polymerase beta knockin mice survive past birth and accumulate base excision repair intermediate substrates.
Authors: Senejani A, Dalal S, Liu Y, Nottoli T, McGrath J, Clairmont C, Sweasy J
Proc Natl Acad Sci U S A, 2012-04-09;109(17):6632-7.  2012-04-09

Nongenotoxic apoptosis inducers do not produce misleading positive results in the TK6 cell-based GADD45a-GFP genotoxicity assay.
Authors: Topham C, Billinton N, Walmsley R
Toxicol Sci, 2012-04-05;128(1):79-91.  2012-04-05

Effects of chronic exposure to an environmentally relevant mixture of brominated flame retardants on the reproductive and thyroid system in adult male rats.
Authors: Ernest S, Wade M, Lalancette C, Ma Y, Berger R, Robaire B, Hales B
Toxicol Sci, 2012-03-02;127(2):496-507.  2012-03-02

CK2 inhibitor CX-4945 suppresses DNA repair response triggered by DNA-targeted anticancer drugs and augments efficacy: mechanistic rationale for drug combination therapy.
Authors: Siddiqui-Jain A, Bliesath J, Macalino D, Omori M, Huser N, Streiner N, Ho C, Anderes K, Proffitt C, O'Brien S, Lim J, Von Hoff D, Ryckman D, Rice W, Drygin D
Mol Cancer Ther, 2012-01-20;11(4):994-1005.  2012-01-20

Oncolytic virus-mediated manipulation of DNA damage responses: synergy with chemotherapy in killing glioblastoma stem cells.
Authors: Kanai R, Rabkin S, Yip S, Sgubin D, Zaupa C, Hirose Y, Louis D, Wakimoto H, Martuza R
J Natl Cancer Inst, 2011-12-15;104(1):42-55.  2011-12-15