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Compound W

Catalog #: 2654
2 Citations Datasheet / COA / SDS

Discontinued Product

2654 has been discontinued.
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Compound W | CAS No. 173550-33-9 | Secretase Inhibitors
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Description: γ-secretase inhibitor
Alternative Names: CW

Chemical Name: 3,5-Bis(4-nitrophenoxy)benzoic acid

Purity: ≥99%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Compound W is an inhibitor of γ-secretase; causes a decrease in the released levels of Aβ42 and notch-1 Aβ-like peptide 25 (Nβ25).

Technical Data

M.Wt:
396.31
Formula:
C19H12N2O8
Solubility:
Soluble to 50 mM in 1.1eq. NaOH and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
173550-33-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes.
    Maury Y, Come J, Piskorowski R, Salah-Mohellibi N, Chevaleyre V, Peschanski M, Martinat C, Nedelec S
    Nat Biotechnol, 2015;33(1):89-96.
  2. Secretion of the notch-1 Aβ-like peptide during notch signaling.
    Okochi et al.
    J.Biol.Chem., 2006;281:7890

Product Datasheets

Reconstitution Calculator
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Reconstitution Calculator

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Citations for Compound W

The citations listed below are publications that use Tocris products. Selected citations for Compound W include:

2 Citations: Showing 1 - 2

  1. Differential Inhibition of Signal Peptide Peptidase Family Members by Established γ-Secretase Inhibitors.
    Authors: Ran Et al.
    PLoS One  2015;10:e0128619
  2. Canonical Notch signalling is inactive in urothelial carcinoma.
    Authors: Greife Et al.
    BMC Cancer  2014;14:628

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