CP 339818 hydrochloride
Discontinued Product
Chemical Name: N-[1-(Phenylmethyl)-4(1H)-quinolinylidene]-1 pentanamine hydrochloride
Purity: ≥99%
Biological Activity
CP 339818 hydrochloride is a potent, non-peptide KV1.3 channel antagonist that preferentially binds to the C-type inactivated state of the channel (IC50 ~ 200 nM). Inhibits KV1.4 with an IC50 of ~ 300 nM. Selective over KV1.1, KV1.2, KV1.5, KV1.6, KV3.1-4, and KV4.2.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated.
Jager et al.
J.Physiol., 1998;506:291 -
Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation.
Nguyen et al.
Mol.Pharmacol., 1996;50:1672
Product Datasheets
Citation for CP 339818 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for CP 339818 hydrochloride include:
1 Citation: Showing 1 - 1
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Kv1 channels and neural processing in vestibular calyx afferents.
Authors: Meredith Et al.
J Neurosci 2015;9:85
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