CP 43
Chemical Name: N-(2-Oxo-2-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)ethyl)-[1,1'-biphenyl]-4-carboxamide
Purity: ≥98%
Biological Activity
CP 43 is a potent TAO kinase (TAOK) inhibitor (IC50 values are 11 nM/L and 15 nM/L for TAOK1 and TAOK2, respectively). Inhibits TAOK phosphorylation and activation of JNK in vitro. Prolongs duration of mitosis and increases mitotic cell death in the SKBR3 breast cancer cell line. Also reduces tau phopshorylation in cortical neurons at sites associated with neurodegeneration in human tauopathies.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Targeting TAO kinase using a new inhibitor compound delays mitosis and induces mitotic cell death in centrosome amplified breast cancer cells.
Koo et al.
Mol.Cancer Ther., 2017;16:2410 -
A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies.
Giacomini et al.
Acta Neuropathol.Commun., 2018;6:37
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Citation for CP 43
The citations listed below are publications that use Tocris products. Selected citations for CP 43 include:
1 Citation: Showing 1 - 1
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TAOK2 is an ER-localized kinase that catalyzes the dynamic tethering of ER to microtubules.
Authors: Smita Et al.
Dev Cell 2021;56:3321-3333.e5
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