CP 465022 hydrochloride
Chemical Name: 3-(2-Chlorophenyl)-2-[2-[6-[(diethylamino)methyl]-2-pyridinyl]ethenyl]-6-fluoro-4(3H)-quinazolinone hydrochloride
Purity: ≥99%
Biological Activity
CP 465022 hydrochloride is a selective, non-competitive AMPA antagonist (IC50 = 25 nM in rat cortical neurons) that displays potent anticonvulsant activity. Also significantly blocks the persistent component of Nav1.6 channel activity. Brain penetrant and orally active.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Functional characterization of CP-465,022, a selective, noncompetitive AMPA receptor antagonist.
Lazaro et al.
Neuropharmacology, 2002;42:143 -
CP-465,022, a selective noncompetitive AMPA receptor antagonist, blocks AMPA receptors but is not neuroprotective in vivo.
Menniti et al.
Stroke, 2003;34:171 -
Traditional AMPA receptor antagonists partially block Nav1.6-mediated persistent current.
Welch et al.
Neuropharmacology, 2008;55:1165
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